Journal article
Prenatal exposure to cocaine selectively disrupts motor responding to D-amphetamine in young and mature rabbits
Neuropharmacology, v 35(1), pp 71-78
Jan 1996
PMID: 8684599
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Abstract
Acute administration of D-amphetamine probed the functional effects of prenatal exposure to cocaine on the integrity of monoaminergic systems in preweanling (48-56 days old) and adult (> or = 140 days old) Dutch belted rabbits. D-Amphetamine sulfate (0, 0.3, 1.0, 3.3 and 6.0 mg/kg, s.c.) produced equivalent dose-related reductions in food intake in 180 day-old rabbits that had been exposed in utero on gestational days 8-29 to cocaine or saline. Intrauterine exposure to cocaine also did not alter the incidence of exploratory behaviors stimulated by D-amphetamine during the anorexia test. In contrast, however, prenatal cocaine virtually eliminated stereotyped head bobbing elicited by the highest dose of D-amphetamine. When responses to 5.0 mg/kg D-amphetamine were measured during a 90-min open field test, prenatal cocaine prevented head bobbing in preweanling rabbits and reduced this behavior by 92% in 140 day-old adults. Prenatal cocaine also diminished the intensity of other motor responses in the open field in the adults but not in preweanlings. In normal rabbits, the D1 antagonist R(+)-SCH 23390 (0.01 mg/kg, s.c.) blocked D-amphetamine-induced head bobbing. Thus, prenatal exposure to cocaine produces an early and persistent deficit in behavioral responding to a high dose of D-amphetamine. The deficit is especially selective at the time of weaning, broadens to affect more motor behaviors with maturation and may reveal impaired D,-mediated dopaminergic neurotransmission in the brain.
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Details
- Title
- Prenatal exposure to cocaine selectively disrupts motor responding to D-amphetamine in young and mature rabbits
- Creators
- K J Simansky - Department of Pharmacology, Medical College of Pennsylvania, Philadelphia, USAW J Kachelries
- Publication Details
- Neuropharmacology, v 35(1), pp 71-78
- Publisher
- Elsevier; England
- Grant note
- P01-DA06871 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1996TX48900009
- Scopus ID
- 2-s2.0-0030041833
- Other Identifier
- 991014877902804721
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- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy