Journal article
Prenatal opioid exposure and the early life epigenome: results from ECHO
Journal of substance use, v 30(3), pp 484-491
2025
PMID: 40589795
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundPrenatal opioid exposure has been associated with adverse child health outcomes. Changes to the epigenome provide a plausible mechanism through which effects may be elicited. We investigated whether prenatal opioid exposure was associated with locus-specific changes in umbilical cord blood DNA methylation (DNAm) and gestational epigenetic age.MethodsWe leveraged data from the Environmental influences on Child Health Outcomes cohort. Prenatal opioid data was obtained from maternal self-report and/or medical record data. DNAm measures were generated from blood biospecimens collected at birth. Linear regression models tested associations between prenatal maternal opioid exposure and epigenetic outcomes in crude and fully adjusted models.ResultsWe tested the association between prenatal opioid exposure and cord blood DNAm at 15 CpG sites in 385 (n = 25 exposed, n = 360 unexposed) individuals from three cohorts. We identified a single CpG site (cg14303187) that was nominally associated with prenatal opioid exposure (p = 0.02, beta = -0.012; 95% CI, -0.023 to -0.0012). No significant associations between exposure and gestational epigenetic age were found (n = 716 individuals from eight cohorts; n = 29 exposed, n = 687 unexposed).ConclusionsWe identified a nominally significant association between prenatal opioid exposure and DNAm at one CpG site. Future studies should continue investigating the effect of this exposure on the epigenome.
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Details
- Title
- Prenatal opioid exposure and the early life epigenome: results from ECHO
- Creators
- Rose Schrott - Johns Hopkins UniversityHenri Garrison-Desany - Harvard UniversityLyndsay Avalos - Kaiser PermanenteCarrie V. Breton - University of Southern CaliforniaDana M. Dabelea - University of Colorado Anschutz Medical CampusKaren Derefinko - University of Tennessee Health Science CenterAnne Dunlop - Emory UniversityFang Fang - RTI InternationalAbigail Gaylord - Columbia UniversityTorie Grant - Johns Hopkins UniversityMarie-France Hivert - College Station Medical CenterMargaret R. Karagas - Dartmouth CollegeAnna K. Knight - Emory UniversityBarry Lester - Brown UniversityKristen Lyall - Drexel UniversityCindy McEvoy - Oregon Health & Science UniversityRuby Nguyen - University of MinnesotaGrier Page - RTI InternationalAlison Paquette - University of WashingtonDouglas Ruden - Wayne State UniversityLyndsey E. Shorey-Kendrick - Oregon National Primate Research CenterAlicia K. Smith - Emory UniversityEliot Spindel - Oregon National Primate Research CenterHeather E. Volk - Johns Hopkins UniversityChristine Ladd-Acosta - Johns Hopkins UniversityProgram Collaborators Environm
- Publication Details
- Journal of substance use, v 30(3), pp 484-491
- Publisher
- Taylor & Francis
- Number of pages
- 8
- Grant note
- U2COD023375; U24OD023382; U24OD023319 / Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health UH3OD023318; UH3OD023287; UH3OD023275; UH3OD023271; UH3OD023342; UH3OD023286; UH3OD023285; UH3OD023305; UH3OD023248; UH3OD023288; UH3OD023347 / Office of Behavioral and Social Science Research (PRO Core)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001235686200001
- Scopus ID
- 2-s2.0-105011625593
- Other Identifier
- 991022197411704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Substance Abuse