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Prenatal risk factors for childhood CKD
Journal article   Open access

Prenatal risk factors for childhood CKD

Christine W Hsu, Kalani T Yamamoto, Rohan K Henry, Anneclaire J De Roos and Joseph T Flynn
Journal of the American Society of Nephrology, v 25(9), pp 2105-2111
Sep 2014
DOI: https://doi.org/10.1681/ASN.2013060582
PMID: 24744441
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1681/asn.2013060582View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open
url
https://doi.org/10.1681/ASN.2013060582View
Published, Version of Record (VoR) Open

Abstract

Adolescent Adult Birth Weight Case-Control Studies Child Child, Preschool Diabetes, Gestational Female Humans Infant Infant, Low Birth Weight Infant, Newborn Male Obesity - complications Odds Ratio Overweight - complications Pregnancy Pregnancy in Diabetics Prenatal Exposure Delayed Effects - etiology Prevalence Renal Insufficiency, Chronic - classification Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - etiology Risk Factors Washington - epidemiology Young Adult
Development of CKD may be programmed prenatally. We sought to determine the association of childhood CKD with prenatal risk factors, including birth weight, maternal diabetes mellitus (DM), and maternal overweight/obesity. We conducted a population-based, case-control study with 1994 patients with childhood CKD (<21 years of age at diagnosis) and 20,032 controls in Washington state. We linked maternal and infant characteristics in birth records from 1987 to 2008 to hospital discharge data and used logistic regression analysis to assess the association of prenatal risk factors with childhood CKD. The prevalence of CKD was 126.7 cases per 100,000 births. High birth weight and maternal pregestational DM associated nominally with CKD, with respective crude odds ratios (ORs) of 1.17 (95% confidence interval [95% CI], 1.03 to 1.34) and 1.97 (95% CI, 1.15 to 3.37); however, adjustment for maternal confounders attenuated these associations to 0.97 (95% CI, 0.79 to 1.21) and 1.19 (95% CI, 0.51 to 2.81), respectively. The adjusted ORs for CKD associated with other prenatal factors were 2.88 (95% CI, 2.28 to 3.63) for low birth weight, 1.54 (95% CI, 1.13 to 2.09) for maternal gestational DM, 1.24 (95% CI, 1.05 to 1.48) for maternal overweight, and 1.26 (95% CI, 1.05 to 1.52) for maternal obesity. In subgroup analysis by CKD subtype, low birth weight and maternal pregestational DM associated significantly with increased risk of renal dysplasia/aplasia. Low birth weight, maternal gestational DM, and maternal overweight/obesity associated significantly with obstructive uropathy. These data suggest that prenatal factors may impact the risk of CKD. Future studies should aim to determine if modification of these factors could reduce the risk of childhood CKD.

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99 citations in Web of Science
105 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#5 Gender Equality
#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Urology & Nephrology
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