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https://scholarship.libraries.rutgers.edu/esploro/outputs/acceptedManuscript/Prenatal-tobacco-exposure-predicts-differential-brain/991031549919904646
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Prenatal tobacco exposure predicts differential brain function during working memory in early adolescence: a preliminary investigation
Brain imaging and behavior, v 7(1)
01 Mar 2013
PMID: 22820891
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Children prenatally exposed to tobacco exhibit higher rates of learning and emotional-behavioral problems related to worse working memory performance. Brain function, however, among tobacco exposed children while performing a working memory task has not previously been examined. This study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a number N-back working memory task using an event-related functional magnetic resonance imaging (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, and sex were statistically controlled. Tobacco-exposed children showed greater activation in inferior parietal regions, whereas unexposed children showed greater activation in inferior frontal regions. These differences were observed in the context of correct responses, suggesting that exposed and unexposed children use different brain regions and approaches to succeed in working memory tasks. Implications for future research and intervention are discussed.
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Details
- Title
- Prenatal tobacco exposure predicts differential brain function during working memory in early adolescence: a preliminary investigation
- Creators
- David S. Bennett - Drexel UniversityFeroze B. Mohamed - Temple UniversityDennis P. Carmody - Rutgers, The State University of New JerseyMuhammed Malik - Temple UniversityScott H. Faro - Temple UniversityMichael Lewis - Rutgers, The State University of New Jersey
- Publication Details
- Brain imaging and behavior, v 7(1)
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- 4100011451 / Pennsylvania Department of Health DA07109 / National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission R01DA007109 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000315466200005
- Scopus ID
- 2-s2.0-84874540917
- Other Identifier
- 991019168575804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neuroimaging