Journal article
Preoperative Statin Use is Associated With Lower Incidence of Limb Loss After Lower Extremity Endovascular Interventions
The American surgeon, Vol.88(11), 00031348211068000
01 Nov 2022
PMID: 35166610
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
Statin therapy is the primary lipid-lowering agent used in peripheral artery disease (PAD) patients. Although the benefits of statins have been described in the literature, most studies have focused on postoperative statin use and outcomes in major upper body vasculature. Our study aimed to assess the impact of statin therapy on postoperative outcomes of lower extremity endovascular interventions including mortality and amputation rates.
Methods
American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2012 to 2019 was utilized for this study. Patients were divided into 2 groups: those on preoperative statins (Group I) and those not on statins (Group II). Univariate and multivariate analyses were performed to assess statin’s effect on postoperative outcomes.
Results
A total of 12,217 patients (72.7%) were in Group I and 4599 patients (27.3%) were in Group II. The distribution of primary outcomes was as follows: Amputation (Group I: 3% vs Group II: 3.9%, P <.05) and Mortality (Group I: 1.6% vs Group II: 1.9%, P = .086). Statin use was associated with decreased amputation rates. Patients with tissue loss were 5 times more likely to undergo amputations (AOR: 5.58 [CI 2.29-13.63] P < .01) within 30-days postoperatively as compared to those whose presenting symptoms were claudication.
Conclusion
Statin therapy was associated with a decreased limb loss within 30-days after intervention at the time of lower extremity endovascular intervention. Patients presenting with rest pain and tissue loss had a higher incidence of limb loss than claudicants.
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Details
- Title
- Preoperative Statin Use is Associated With Lower Incidence of Limb Loss After Lower Extremity Endovascular Interventions
- Creators
- Ahsan Zil-E-Ali - Penn State Milton S. Hershey Medical CenterDaniela Medina - Pennsylvania State UniversityDavid Orozco - Office of Medical Education, Drexel University College of Medicine, 12310Philadelphia, PA, USAQian Yang - Office of Medical Education, The Pennsylvania State University College of Medicine12310, Hershey, PA, USAFaisal Aziz - Penn State Milton S. Hershey Medical Center
- Publication Details
- The American surgeon, Vol.88(11), 00031348211068000
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Drexel University
- Web of Science ID
- WOS:000759453000001
- Scopus ID
- 2-s2.0-85125070349
- Other Identifier
- 991021860725604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery