Journal article
Preparation of cationic nanogels for nucleic acid delivery
Biomacromolecules, v 13(11), pp 3445-3449
12 Nov 2012
PMID: 22967138
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cationic nanogels with site-selected functionality were designed for the delivery of nucleic acid payloads targeting numerous therapeutic applications. Functional cationic nanogels containing quaternized 2-(dimethylamino)ethyl methacrylate and a cross-linker with reducible disulfide moieties (qNG) were prepared by activators generated by electron transfer (AGET) atom transfer radical polymerization (ATRP) in an inverse miniemulsion. Polyplex formation between the qNG and nucleic acid exemplified by plasmid DNA (pDNA) and short interfering RNA (siRNA duplexes) were evaluated. The delivery of polyplexes was optimized for the delivery of pDNA and siRNA to the Drosophila Schneider 2 (S2) cell-line. The qNG/nucleic acid (i.e., siRNA and pDNA) polyplexes were found to be highly effective in their capabilities to deliver their respective payloads.
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Details
- Title
- Preparation of cationic nanogels for nucleic acid delivery
- Creators
- Saadyah E Averick - Carnegie Mellon UniversityEduardo ParedesAinara Irastorza - Carnegie Mellon UniversityArun R Shrivats - Carnegie Mellon UniversityAbiraman SrinivasanDaniel J SiegwartAndrew J MagenauHong Y ChoEric Hsu - Carnegie Mellon UniversityAmram A AverickJinku Kim - Carnegie Mellon UniversityShiguang Liu - Carnegie Mellon UniversityJeffrey O Hollinger - Carnegie Mellon UniversitySubha R DasKrzysztof Matyjaszewski
- Publication Details
- Biomacromolecules, v 13(11), pp 3445-3449
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering; Neurosurgery
- Web of Science ID
- WOS:000310931900003
- Scopus ID
- 2-s2.0-84869011620
- Other Identifier
- 991020531965104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Organic
- Polymer Science