Journal article
Preparation of novel biodegradable ternary copolymers mPEG-b-P(MCC-g-OEI) and their gene delivery
Journal of controlled release, v 152, pp e139-e140
30 Nov 2011
PMID: 22195806
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A series of biodegradable mPEG-b-P(MCC-g-OEI) (PPO) copolymers were synthesized by grafting oligoethylenimines (OEIs) with different molecular weights to mPEG-b-PMCC. PPO600 and PPO1800 could efficiently condense DNA into nanosized particles (100–140nm) with positive charges. The in vitro gene transfection showed that the PPO copolymers had great potential as non-viral gene vectors, especially the PPO1800, which exhibited higher gene transfection efficiency than PEI25k in absence of serum in CHO cells.
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Details
- Title
- Preparation of novel biodegradable ternary copolymers mPEG-b-P(MCC-g-OEI) and their gene delivery
- Creators
- Xuan Dong - Chinese Academy of SciencesLei Chen - Chinese Academy of SciencesHuayu Tian - Chinese Academy of SciencesJie Chen - Chinese Academy of SciencesXuesi Chen - Chinese Academy of SciencesYen Wei - Drexel UniversityAtsushi Maruyama - Kyushu UniversityTae Gwan Park - Korea Advanced Institute of Science and Technology
- Publication Details
- Journal of controlled release, v 152, pp e139-e140
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000299125600094
- Scopus ID
- 2-s2.0-84861218789
- Other Identifier
- 991019168589404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Pharmacology & Pharmacy