Journal article
Preparation of omega trideuterated sulfidopeptide leukotrienes: Analysis by FAB/MS
Prostaglandins, v 37(2), pp 251-258
01 Feb 1989
PMID: 2543036
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
C-20 Trideuterated leukotriene A
4 methyl ester was prepared by Wittig condensation of a deuterated C
9-phosphonium salt with a C
11-epoxydienal. It was then treated separately with glutathione, cysteinylglycine and cysteine. The resulting esters were saponified to give C-20 trideuterated leukotrienes C
4, D
4 and E
4 respectively. Fast atom bombardment mass spectrometry showed that the synthetic compounds contained from 0.5 to 1.0 % protium impurity. Introduction of deuterium at C-20 ensures that it is stable t a wide variety of reagents and reaction conditions. The deuterated leukotrienes will serve as internal standard for the quantitative analysis by mass spectrometry of endogenous sulfidopeptide leukotrienes present in biological fluids.
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Details
- Title
- Preparation of omega trideuterated sulfidopeptide leukotrienes: Analysis by FAB/MS
- Creators
- C. Prakash - Vanderbilt UniversityB.J. Sweetman - Vanderbilt UniversityR. Sivakumar - Biomol Research Laboratories, Inc., 5166 Campus Drive, Plymouth Meeting, PA 19462, USAI.M. Taffer - Orthopaedic Research LaboratoriesR.E. Zipkin - Orthopaedic Research LaboratoriesI.A. Blair - Vanderbilt UniversityVanderbilt Univ., Nashville, TN (USA)
- Publication Details
- Prostaglandins, v 37(2), pp 251-258
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Arts and Sciences
- Web of Science ID
- WOS:A1989T826800008
- Scopus ID
- 2-s2.0-0024562849
- Other Identifier
- 991021229980104721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology