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Prescribing Patterns of Proprotein Convertase Subtilisin-Kexin Type 9 Inhibitors in Eligible Patients With Clinical Atherosclerotic Cardiovascular Disease or Heterozygous Familial Hypercholesterolemia
Journal article   Open access   Peer reviewed

Prescribing Patterns of Proprotein Convertase Subtilisin-Kexin Type 9 Inhibitors in Eligible Patients With Clinical Atherosclerotic Cardiovascular Disease or Heterozygous Familial Hypercholesterolemia

Dean G. Karalis, Usha G. Mallya, Ameen F. Ghannam, Joseph Elassal, Rishab Gupta and Susan H. Boklage
The American journal of cardiology, v 121(10), pp 1155-1161
15 May 2018
DOI: https://doi.org/10.1016/j.amjcard.2018.02.002
PMID: 29548678
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://www.ajconline.org/article/S0002914918301851/pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1016/j.amjcard.2018.02.002View
Published, Version of Record (VoR) Open

Abstract

Two proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are approved for patients with atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia who require additional low-density lipoprotein cholesterol (LDL-C) lowering. This retrospective study sought to determine differences between eligible patients who were prescribed and those who were not prescribed a PCSK9 inhibitor. Patients from an electronic medical record database were included in the analysis, and their demographic, clinical, and treatment characteristics were evaluated. Of 368,624 PCSK9 inhibitor-eligible patients, 1,752 (<0.5%) received a PCSK9 inhibitor prescription. Patients who received a PCSK9 inhibitor were more frequently associated with a higher cardiovascular disease risk category and a higher baseline LDL-C level (139.4 vs 103.5 mg/dl; p <0.0001) compared with those who did not. Patients with a PCSK9 inhibitor prescription were significantly more likely to be on ezetimibe, alone or in combination with a statin, at baseline compared with those without (29% vs 5%; p <0.0001). The use of a PCSK9 inhibitor was very low in the 2 groups of patients identified as PCSK9 inhibitor-eligible based on the American College of Cardiology Expert Consensus Decision Pathway. In conclusion, this study demonstrates that most PCSK9 inhibitor-eligible patients do not receive a PCSK9 inhibitor prescription, highlighting that many high-risk patients could benefit from additional LDL-C lowering with a PCSK9 inhibitor.

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26 citations in Web of Science
25 citations in Scopus

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Collaboration types
Industry collaboration
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Web of Science research areas
Cardiac & Cardiovascular Systems
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