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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Prescription patterns of opioids and non-steroidal anti-inflammatory drugs in the first year after living kidney donation: An analysis of US Registry and Pharmacy fill records
CLINICAL TRANSPLANTATION, v 34(8), e14000
Aug 2020
PMID: 32502285
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined a novel database linking national donor registry identifiers to records from a US pharmaceutical claims warehouse (2007-2015) to describe opioid and NSAID prescription patterns among LKDs during the first year postdonation, divided into three periods: 0-14 days, 15-182 days, and 183-365 days. Associations of opioid and NSAID prescription fills with baseline factors were examined by logistic regression (adjusted odds ratio,(LCL)aOR(UCL)). Among 23,565 donors, opioid prescriptions were highest during days 0-14 (36.6%), but 12.6% of donors filled opioids during days 183-365. NSAID prescriptions rose from 0.5% during days 0-14 to 3.3% during days 183-365. Women filled opioids more commonly than men, and black donors filled both opioids and NSAIDs more commonly than white donors. After covariate adjustment, significant correlates of opioid prescription fills during days 183-365 included obesity (aOR,(1.24)1.38(1.53)), less than college education (aOR,(1.19)1.31(1.43)), smoking (aOR,(1.33)1.45(1.58)), and nephrectomy complications (aOR,(1.11)1.29(1.49)). NSAID prescription fills in year 1 were not associated with differences in estimated glomerular filtration rate, incidence of proteinuria or new-onset hypertension at the first and second year postdonation. Prescription fills for opioids and NSAIDs for LKDs varied with demographic and clinic traits. Future work should examine longer-term outcome implications to help inform safe analgesic regimen choices after donation.
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Details
- Title
- Prescription patterns of opioids and non-steroidal anti-inflammatory drugs in the first year after living kidney donation: An analysis of US Registry and Pharmacy fill records
- Publication Details
- CLINICAL TRANSPLANTATION, v 34(8), e14000
- Publisher
- WILEY; HOBOKEN
- Grant note
- National Institute of Diabetes and Digestive and Kidney Diseases, Grant/Award Number: R01DK120551
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000543820200001
- Scopus ID
- 2-s2.0-85087173252
- Other Identifier
- 991021860768104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Surgery
- Transplantation