Journal article
Prescription patterns of opioids and non-steroidal anti-inflammatory drugs in the first year after living kidney donation: An analysis of US Registry and Pharmacy fill records
Clinical transplantation, v 34(8), 14000
Aug 2020
PMID: 32502285
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined a novel database linking national donor registry identifiers to records from a US pharmaceutical claims warehouse (2007-2015) to describe opioid and NSAID prescription patterns among LKDs during the first year postdonation, divided into three periods: 0-14 days, 15-182 days, and 183-365 days. Associations of opioid and NSAID prescription fills with baseline factors were examined by logistic regression (adjusted odds ratio,(LCL)aOR(UCL)). Among 23,565 donors, opioid prescriptions were highest during days 0-14 (36.6%), but 12.6% of donors filled opioids during days 183-365. NSAID prescriptions rose from 0.5% during days 0-14 to 3.3% during days 183-365. Women filled opioids more commonly than men, and black donors filled both opioids and NSAIDs more commonly than white donors. After covariate adjustment, significant correlates of opioid prescription fills during days 183-365 included obesity (aOR,(1.24)1.38(1.53)), less than college education (aOR,(1.19)1.31(1.43)), smoking (aOR,(1.33)1.45(1.58)), and nephrectomy complications (aOR,(1.11)1.29(1.49)). NSAID prescription fills in year 1 were not associated with differences in estimated glomerular filtration rate, incidence of proteinuria or new-onset hypertension at the first and second year postdonation. Prescription fills for opioids and NSAIDs for LKDs varied with demographic and clinic traits. Future work should examine longer-term outcome implications to help inform safe analgesic regimen choices after donation.
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Details
- Title
- Prescription patterns of opioids and non-steroidal anti-inflammatory drugs in the first year after living kidney donation: An analysis of US Registry and Pharmacy fill records
- Creators
- Luke S. Vest - Saint Louis UniversityNagaraju Sarabu - University Hospitals of ClevelandFarrukh M. Koraishy - Saint Louis UniversityMinh-Tri Nguyen - College Station Medical CenterMeyeon Park - University of California, San FranciscoNgan N. Lam - University of AlbertaMark A. Schnitzler - Saint Louis UniversityDavid Axelrod - University of IowaChi Yuan Hsu - UCSF, Dept Med, Nephrol, San Francisco, CA USAAmit X. Garg - Western UniversityDorry L. Segev - New York UniversityAllan B. Massie - National Institute of Allergy and Infectious DiseasesGregory P. Hess - Drexel Univ, Sch Med, Philadelphia, PA 19104 USABertram L. Kasiske - Hennepin County Medical CenterKrista L. Lentine - St Louis Univ, Sch Med, Ctr Abdominal Transplantat, St Louis, MO USA
- Publication Details
- Clinical transplantation, v 34(8), 14000
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- R01DK120551 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01DK120518; R01DK120551 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000543820200001
- Scopus ID
- 2-s2.0-85087173252
- Other Identifier
- 991021860768104721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Surgery
- Transplantation