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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood
Environmental research, v 144(Pt A)
01 Jan 2016
PMID: 26610292
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prenatal exposure to tobacco smoke has lifelong health consequences. Epigenetic signatures such as differences in DNA methylation (DNAm) may be a biomarker of exposure and, further, might have functional significance for how in utero tobacco exposure may influence disease risk. Differences in infant DNAm associated with maternal smoking during pregnancy have been identified. Here we assessed whether these infant DNAm patterns are detectible in early childhood, whether they are specific to smoking, and whether childhood DNAm can classify prenatal smoke exposure status. Using the lnfinium 450 K array, we measured methylation at 26 CpG loci that were previously associated with prenatal smoking in infant cord blood from 572 children, aged 3-5, with differing prenatal exposure to cigarette smoke in the Study to Explore Early Development (SEED). Striking concordance was found between the pattern of prenatal smoking associated DNAm among preschool aged children in SEED and those observed at birth in other studies. These DNAm changes appear to be tobacco-specific. Support vector machine classification models and 10-fold cross-validation were applied to show classification accuracy for childhood DNAm at these 26 sites as a biomarker of prenatal smoking exposure. Classification models showed prenatal exposure to smoking can be assigned with 81% accuracy using childhood DNAm patterns at these 26 loci. These findings support the potential for blood-derived DNAm measurements to serve as biomarkers for prenatal exposure. (C) 2015 Elsevier Inc. All rights reserved.
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Details
- Title
- Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood
- Creators
- Christine Ladd-Acosta - BloombergChang Shu - Johns Hopkins UniversityBrian K. Lee - Drexel UniversityNicole Gidaya - Drexel UniversityAlison Singer - Johns Hopkins UniversityLaura A. Schieve - Centers for Disease Control and PreventionDiana E. Schendel - Aarhus UniversityNicole Jones - Michigan State UniversityJulie L. Daniels - University of North Carolina at Chapel HillGayle C. Windham - California Health and Human Services AgencyCraig J. Newschaffer - Drexel UniversityLisa A. Croen - Kaiser PermanenteAndrew P. Feinberg - Center for Epigenetics, Institute for Basic Biomedical Science, Johns Hopkins School of Medicine, Baltimore, MD, USAM. Daniele Fallin - Johns Hopkins University
- Publication Details
- Environmental research, v 144(Pt A)
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- U10DDD000183 / Johns Hopkins University U10DD000184 / University of North Carolina at Chapel Hill U10DD000180 / Centers for Disease Control and Prevention: Colorado Department of Public Health and Environment U10DD000181 / CENTERS FOR DISEASE CONTROL AND PREVENTION; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA U01DD001214 / National Center on Birth Defects and Developmental Disabilities; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA Autism Speaks U10DD000181 / Kaiser Foundation Research Institute (CA) R155-2014-1724 / Lundbeck Foundation; Lundbeckfonden U10DD000182 / University of Pennsylvania U10DD000498 / Michigan State University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000366438900015
- Scopus ID
- 2-s2.0-84947811911
- Other Identifier
- 991019168913804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health