Journal article
Presentation and Outcomes of Pediatric Myocarditis in the Emergency Department: A Systematic Review and Meta-Analysis
Current emergency and hospital medicine reports, v 13(1), 2
01 Dec 2025
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Abstract
Purpose of Review
Pediatric myocarditis, although rare, is associated with high morbidity and mortality, especially in emergency department (ED) settings where timely diagnosis and intervention are crucial. This systematic review and meta-analysis aim to consolidate current evidence regarding the clinical presentations, diagnostic findings, and outcomes of pediatric myocarditis in the ED, with an emphasis on the need for improved diagnostic and therapeutic strategies.
Recent Findings
A systematic search of PubMed, Scopus, Web of Science, EMBASE, and Medline was conducted through December 2023, identifying 17 studies that met strict inclusion criteria. Across 737 pediatric myocarditis cases, common clinical presentations included poor feeding (60.4%), fever (51%), respiratory distress (49.8%), and hypoperfusion (45.9%). Laboratory findings indicated elevated troponin in 80.4% of cases and increased C-reactive protein in 63.3%. Imaging and ECG data revealed cardiomegaly in 44.7% and ST/T wave abnormalities in 47.5%. Intensive Care Unit (ICU) admission was required for 88.1% of cases, with 46.9% needing mechanical ventilation, and an overall mortality rate of 15.7%.
Summary
Pediatric myocarditis presents with non-specific symptoms, complicating early diagnosis in the ED. High rates of ICU admission and mortality highlight the urgency for rapid identification and timely intervention. Future research should aim to refine diagnostic markers and optimize treatment protocols to improve outcomes in this vulnerable population
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Details
- Title
- Presentation and Outcomes of Pediatric Myocarditis in the Emergency Department: A Systematic Review and Meta-Analysis
- Creators
- Mohammed Alsabri - EMERGENCYAmira Mohamed Taha - Fayoum UniversityKhaled Abouelmagd - Cardiology Department, Faculty of Medicine, Al-Azhar UniversityNouran A. Taha - MARS-GlobalSarah Makram Elsayed - October 6 UniversityMohamed M. Ghonaim - Menoufia UniversityRaghad Samha - Faculty of Medicine, AlBaath UniversityAbdelrahman Abdelshafi - Assiut UniversityNicholas Aderinto - Ladoke Akintola University of Technology Teaching HospitalLuis Gamboa - Drexel University
- Publication Details
- Current emergency and hospital medicine reports, v 13(1), 2
- Publisher
- Springer US
- Number of pages
- 15
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Emergency Medicine
- Web of Science ID
- WOS:001381049400001
- Other Identifier
- 991022005186304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Emergency Medicine