Journal article
Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy In Elderly Subjects Without Alzheimer Disease
Journal of neuropathology and experimental neurology, v 67(12), pp 1205-1212
Dec 2008
PMID: 19018241
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cerebral volume loss has long been associated with normal aging but whether this is due to aging itself or to age-related diseases including incipient Alzheimer disease (AD) is uncertain. To understand the changes that occur in the aging brain, we examined the cerebral cortex of 27 normal individuals ranging in age from 56 to 103 years. None fulfilled the criteria for the neuropathological diagnosis of AD or other neurodegenerative disease. Seventeen of the elderly participants had cognitive testing an average of 6.7 months prior to death. We used quantitative approaches to analyze cortical thickness, neuronal number, and density. Frontal and temporal neocortical regions had clear evidence of cortical thinning with age but total neuronal numbers in frontal and temporal neocortical regions remained relatively constant over a 50-year age range. These data suggest that loss of neuronal and dendritic architecture, rather than loss of neurons, underlies neocortical volume loss with increasing age in the absence of AD.
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Details
- Title
- Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy In Elderly Subjects Without Alzheimer Disease
- Creators
- Stefanie H Freeman - C.S. Kubik Laboratory for Neuropathology, Department of PathologyRuth Kandel - Hebrew Senior Life and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MALuis Cruz - Center for Polymer Studies, Department of Physics, Boston University, Boston, MAAnete Rozkalne - Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MAKathy Newell - Department of Pathology, University of Kansas Medical Center, Kansas City, KSMatthew P Frosch - C.S. Kubik Laboratory for Neuropathology, Department of PathologyE. Tessa Hedley-Whyte - C.S. Kubik Laboratory for Neuropathology, Department of PathologyJoseph J Locascio - Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MALewis Lipsitz - Hebrew Senior Life and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MABradley T Hyman - C.S. Kubik Laboratory for Neuropathology, Department of Pathology
- Publication Details
- Journal of neuropathology and experimental neurology, v 67(12), pp 1205-1212
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000261352100009
- Scopus ID
- 2-s2.0-58149399367
- Other Identifier
- 991014878046104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Pathology