Journal article
Presynaptic dopamine modulation by stimulant self-administration
Frontiers in bioscience (Scholar edition), v 5(1), pp 261-276
01 Jan 2013
PMID: 23277050
Abstract
The mesolimbic dopamine system is an essential participant in the initiation and modulation of various forms of goal-directed behavior, including drug reinforcement and addiction processes. Dopamine neurotransmission is increased by acute administration of all drugs of abuse, including the stimulants cocaine and amphetamine. Chronic exposure to these drugs via voluntary self-administration provides a model of stimulant abuse that is useful in evaluating potential behavioral and neurochemical adaptations that occur during addiction. This review describes commonly used methodologies to measure dopamine and baseline parameters of presynaptic dopamine regulation, including exocytotic release and reuptake through the dopamine transporter in the nucleus accumbens core, as well as dramatic adaptations in dopamine neurotransmission and drug sensitivity that occur with acute non-contingent and chronic, contingent self-administration of cocaine and amphetamine.
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21 citations in Scopus
Details
- Title
- Presynaptic dopamine modulation by stimulant self-administration
- Creators
- Rodrigo A Espana - Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USASara R Jones
- Publication Details
- Frontiers in bioscience (Scholar edition), v 5(1), pp 261-276
- Publisher
- United States
- Grant note
- R01 DA021325 / NIDA NIH HHS R01 DA030161 / NIDA NIH HHS P50 DA006634 / NIDA NIH HHS R21 DA018815 / NIDA NIH HHS K01 DA025279 / NIDA NIH HHS P50 DA06634 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Scopus ID
- 2-s2.0-84883723374
- Other Identifier
- 991014877821804721