Journal article
Prevalence and distribution of Plasmodium vivax Duffy Binding Protein gene duplications in Sudan
PloS one, v 18(7), pe0287668
20 Jul 2023
PMID: 37471337
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Plasmodium vivax Duffy Binding Protein (PvDBP) is essential for interacting with Duffy antigen receptor for chemokines (DARC) on the surface of red blood cells to allow invasion. Earlier whole genome sequence analyses provided evidence for the duplications of PvDBP. It is unclear whether PvDBP duplications play a role in recent increase of P. vivax in Sudan and in Duffy-negative individuals. In this study, the prevalence and type of PvDBP duplications, and its relationship to demographic and clinical features were investigated. A total of 200 malaria-suspected blood samples were collected from health facilities in Khartoum, River Nile, and Al-Obied. Among them, 145 were confirmed to be P. vivax, and 43 (29.7%) had more than one PvDBP copies with up to four copies being detected. Both the Malagasy and Cambodian types of PvDBP duplication were detected. No significant difference was observed between the two types of duplications between Duffy groups. Parasitemia was significantly higher in samples with the Malagasy-type than those without duplications. No significant difference was observed in PvDBP duplication prevalence and copy number among study sites. The functional significance of PvDBP duplications, especially those Malagasy-type that associated with higher parasitemia, merit further investigations.
Metrics
1 Record Views
Details
- Title
- Prevalence and distribution of Plasmodium vivax Duffy Binding Protein gene duplications in Sudan
- Creators
- Safaa Ahmed - University of KhartoumKareen F. Pestana - University of North Carolina at CharlotteAnthony Ford - University of North Carolina at CharlotteMohammed Elfaki - University of KhartoumEiman Gamil - University of KhartoumArwa Elamin - University of KhartoumSamuel Omer M. Hamad - University of KhartoumTarig Mohamed Elfaki - University of KhartoumSumaia Mohamed Ahmed Abukashawa - University of KhartoumEugenia Lo - University of North Carolina at CharlotteMuzamil Abdel Hamid - University of Khartoum
- Publication Details
- PloS one, v 18(7), pe0287668
- Publisher
- Public Library Science
- Number of pages
- 13
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:001035045000038
- Scopus ID
- 2-s2.0-85166539273
- Other Identifier
- 991022192027204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Multidisciplinary Sciences