Journal article
Prevalence and incidence of juvenile idiopathic arthritis-associated uveitis and medication trends in the TriNetX database
British journal of ophthalmology, v 110(1), pp 46-51
01 Jan 2026
PMID: 40695571
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aims To investigate the prevalence and incidence of juvenile idiopathic arthritis (JIA)-associated uveitis (JIA-U) in the USA from 2013 to 2023 by analysing the TriNetX database. Secondary outcomes analysed included disease demographics, associated ocular complications and immunosuppressive prescription trends.Methods Patients with JIA-U were identified in the TriNetX database, a large, multicentre research network, through International Classification of Diseases, 10th Edition codes. Data collected included patient demographics, concurrent uveitic ocular complications, incidence, prevalence and cumulative prevalence of JIA-U in the 11-year period and immunosuppressive utilisation in the JIA population.Results 4510 patients with JIA-U were included in this study. The cumulative prevalence and incidence of JIA-U over the 11-year period were 4.4 and 1.2 per 100 000 cases, both of which decreased over the study period. 5.5% of patients with JIA had a diagnosis of uveitis and 36.1% of patients with JIA-U had an associated uveitic ocular adverse event, including glaucoma, band keratopathy, low vision and blindness. The prevalence of immunosuppressive drug therapy in patients with JIA increased over the years 2013-2023.Conclusion In this large US database, the JIA-U prevalence and incidence rates decreased between 2013 and 2023. This may be partially attributed to the increasing prevalence of immunosuppressive drug use in patients with JIA.
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Details
- Title
- Prevalence and incidence of juvenile idiopathic arthritis-associated uveitis and medication trends in the TriNetX database
- Creators
- Rayna Marshall - Drexel UniversityJennifer Thorne - Johns Hopkins UniversityMeghan K. Berkenstock - Johns Hopkins University
- Publication Details
- British journal of ophthalmology, v 110(1), pp 46-51
- Publisher
- Bmj Publishing Group
- Number of pages
- 6
- Grant note
- Hankins Fund Dracopoulos Uveitis Research Fund Kids Uveitis Research and Education (KURE) Fund KURE Fund
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001550938600002
- Scopus ID
- 2-s2.0-105011289979
- Other Identifier
- 991022197325304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology