Journal article
Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988-1994
American journal of epidemiology, v 178(1), pp 38-45
01 Jul 2013
PMID: 23703888
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previous estimates of the prevalence of nonalcoholic fatty liver disease (NAFLD) in the US population relied on measures of liver enzymes, potentially underestimating the burden of this disease. We used ultrasonography data from 12,454 adults who participated in the Third National Health and Nutrition Examination Survey, conducted in the United States from 1988 to 1994. We defined NAFLD as the presence of hepatic steatosis on ultrasonography in the absence of elevated alcohol consumption. In the US population, the rates of prevalence of hepatic steatosis and NAFLD were 21.4% and 19.0%, respectively, corresponding to estimates of 32.5 (95% confidence interval: 29.9, 35.0) million adults with hepatic steatosis and 28.8 (95% confidence interval: 26.6, 31.2) million adults with NAFLD nationwide. After adjustment for age, income, education, body mass index (weight (kg)/height (m)(2)), and diabetes status, NAFLD was more common in Mexican Americans (24.1%) compared with non-Hispanic whites (17.8%) and non-Hispanic blacks (13.5%) (P = 0.001) and in men (20.2%) compared with women (15.8%) (P < 0.001). Hepatic steatosis and NAFLD were also independently associated with diabetes, with insulin resistance among people without diabetes, with dyslipidemia, and with obesity. Our results extend previous national estimates of the prevalence of NAFLD in the US population and highlight the burden of this disease. Men, Mexican Americans, and people with diabetes and obesity are the most affected groups.
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Details
- Title
- Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988-1994
- Creators
- Mariana Lazo - Johns Hopkins UniversityRuben Hernaez - Johns Hopkins UniversityMark S. Eberhardt - Centers for Disease Control and Prevention.Susanne Bonekamp - Johns Hopkins UniversityIhab Kamel - Johns Hopkins UniversityEliseo Guallar - Johns Hopkins UniversityAyman Koteish - Johns Hopkins UniversityFrederick L. Brancati - Johns Hopkins UniversityJeanne M. Clark - Johns Hopkins University
- Publication Details
- American journal of epidemiology, v 178(1), pp 38-45
- Publisher
- Oxford Univ Press
- Number of pages
- 8
- Grant note
- P30DK079637 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01 DK083393-01 / National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) American Diabetes Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Community Health and Prevention
- Web of Science ID
- WOS:000321449400005
- Scopus ID
- 2-s2.0-84880245463
- Other Identifier
- 991020550500304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health