Journal article
Prevalence of hepatitis C virus infection among injection drug users in the United States, 1994-2004
Clinical infectious diseases, v 46(12), pp 1852-1858
15 Jun 2008
PMID: 18462109
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. To examine hepatitis C virus (HCV) seroprevalence among injection drug users in 4 US cities from 1994 through 2004.
Methods. Demographic characteristics, behaviors, and prevalence of HCV antibody among 5088 injection drug users aged 18-40 years from Baltimore, Maryland; Chicago, Illinois; Los Angeles, California; and New York, New York, enrolled in 3 related studies-Collaborative Injection Drug User Study (CIDUS) I (1994-1996), CIDUS II (1997-1999), and CIDUS III/Drug User Intervention Trial (2002-2004)-were compared using the chi(2) and Mantel-Haenszel tests of significance. Trends over time were assessed by logistic regression.
Results. Prevalence of HCV infection was 65%, 35%, and 35% in CIDUS I, CIDUS II, and CIDUS III, respectively. The adjusted prevalence odds ratio (OR) of being HCV antibody positive increased with the number of years of injection drug use (OR, 1.93 [95% confidence interval {CI}, 1.68-2.21] for each year of injecting within the first 2 years; OR, 1.09 [95% CI, 1.07-1.11] for each year of injecting beyond the first 2 years). Significant decreases were observed in the prevalence of HCV antibody between CIDUS I and CIDUS III in Baltimore (OR, 0.30; 95% CI, 0.20-0.43) and Los Angeles (OR, 0.17; 95% CI, 0.09-0.31) and among people of races other than black in Chicago (OR, 0.12; 95% CI, 0.08-0.17). No decrease in prevalence was seen in New York (OR, 1.04; 95% CI, 0.69-1.58) or among blacks in Chicago (OR, 0.55; 95% CI, 0.16-1.90).
Conclusion. Although regional differences exist, our data suggest that the incidence of HCV infection among injection drug users in the United States decreased from 1994 through 2004.
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Details
- Title
- Prevalence of hepatitis C virus infection among injection drug users in the United States, 1994-2004
- Creators
- Joseph J. Amon - Centers for Disease Control and PreventionRichard S. Garfein - Centers for Disease Control and PreventionLinda Ahdieh-Grant - Centers for Disease Control and PreventionGregory L. Armstrong - Centers for Disease Control and PreventionLawrence J. Ouellet - University of Illinois ChicagoMary H. Latka - New York Academy of MedicineDavid Vlahov - New York Academy of MedicineSteffanie A. Strathdee - University of California San DiegoSharon M. Hudson - Hlth Res Assoc, Hollywood, CA USAPeter Kerndt - Los Angeles County Department of Public HealthDon Des Jarlais - College Station Medical CenterIan T. Williams - Centers for Disease Control and Prevention
- Publication Details
- Clinical infectious diseases, v 46(12), pp 1852-1858
- Publisher
- Oxford Univ Press
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Community Health and Prevention
- Web of Science ID
- WOS:000256044900012
- Scopus ID
- 2-s2.0-46249094710
- Other Identifier
- 991021895669204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology