Journal article
Prevalence of obesity in people with and without type 1 diabetes across Belgium, Kuwait, and Mexico: an IMI2 SOPHIA study
EClinicalMedicine, Vol.77, pp.102869-102869
01 Nov 2024
PMID: 39416388
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Individuals with type 1 diabetes (T1D) are traditionally perceived as lean, but recent evidence suggests an increasing trend of obesity. To provide global estimates, this study explored the prevalence of obesity among adults with and without T1D across three distinct global regions. Methods An observational, cross-sectional study was performed utilizing data from T1D registries and national health surveys to assess the prevalence of obesity (BMI >= 30 kg/m(2)) and the prevalence of overweight and obesity (BMI >= 25 kg/m(2)) across Belgium, Kuwait, and Mexico. Demographic and clinical characteristics of adults with and without T1D were assessed. Prevalence estimates were calculated through a binomial generalized linear mixed-effects model adjusting for age, sex, HbA1c, and survey year. As a sensitivity analysis, propensity score matching was performed for confounder adjustment of age and sex. Findings The study encompassed 3594 individuals with T1D (from 2003 to 2022) and 9898 without T1D (from 2014 to 2021). After model adjustment for confounders (age, sex, HbA1c% and data-collection year), individual obesity prevalence was lower in individuals with T1D in Kuwait and Mexico than among those without type 1 diabetes (Kuwait: 22% (CI: 18-26%) vs. 44% (CI: 41-48%); Mexico: 5% (CI: 3-7%) vs. 40% (CI: 38-42%)). In contrast, individuals with T1D in Belgium showed a more comparable proportions to those without T1D (12% (CI: 9-16%) vs. 16% (CI:11-22%)). Interpretation Our data reveal that obesity is prevalent among people with T1D. These findings underscore the need for targeted strategies in T1D care that address the growing concern of obesity.
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Details
- Title
- Prevalence of obesity in people with and without type 1 diabetes across Belgium, Kuwait, and Mexico: an IMI2 SOPHIA study
- Creators
- Ebaa Al Ozairi - Dasman Diabet Inst, Dept Clin Res & Clin Trials, DAFNE Unit, Dasman, KuwaitNele Steenackers - KU LeuvenSofia Pazmino - KU LeuvenAbdulnabi T. Alattar - Dasman Diabetes InstituteJumana Al Kandari - Dasman Diabetes InstitutePaloma Almeda-Valdes - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránNeftali Eduardo Antonio-Villa - Instituto Nacional de CardiologíaCarl Delfin - Novo NordiskRaquel N. Faradji - Centro Médico ABCA. Aili Garcia-Tuomola - College Station Medical CenterMohammad Irshad - Dasman Diabetes InstituteJoseph C. Longenecker - Drexel UniversityJonathan Rosen - BreakthroughCarmen Hurtado del Pozo - BreakthroughThomas Sparso - Novo HoldingsAstrid Lavens - SciensanoChantal Mathieu - KU LeuvenBart van der Schueren - KU LeuvenCarel W. le Roux - University College Dublin
- Publication Details
- EClinicalMedicine, Vol.77, pp.102869-102869
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- 875534 / Innovative Medicines Initiative 2Joint Undertaking European Union; European Union (EU) EFPIA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001331478200001
- Scopus ID
- 2-s2.0-85205353660
- Other Identifier
- 991022051416704721
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- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism