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Preventing neuronal damage and inflammation in vivo during cortical microelectrode implantation through the use of Poloxamer P-188
Journal article   Open access   Peer reviewed

Preventing neuronal damage and inflammation in vivo during cortical microelectrode implantation through the use of Poloxamer P-188

A Misra, P Kondaveeti, J Nissanov, K Barbee, P Shewokis, L Rioux and K A Moxon
Journal of neural engineering, v 10(1), pp 016011-016011
21 Jan 2013
DOI: https://doi.org/10.1088/1741-2560/10/1/016011
PMID: 23337321
url
https://europepmc.org/articles/pmc4470293View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

coating electrode inflammation Poloxamer surface modification
Objective. The aim of this study was to test the efficacy of Poloxamer P188 to reduce cell death and immune response associated with mechanical trauma to cells during implantation of a chronic recording electrode. Approach. Ceramic multi-site recording electrodes were implanted bilaterally into 15 adult male Long-Evans rats. One of each pair was randomly assigned to receive a coating of Poloxamer while the other was treated with saline. The extent of neuron loss, and glial cell recruitment were characterized at 2, 4 and 6 weeks post-implantation by stereologic analysis. Main results. At 2 and 4 weeks post-implantation, Poloxamer-coated implants showed significantly fewer glial cells and more neurons in the peri-electrode space than controls; however, this significance was lost by 6 weeks. Significance. These findings are the first to suggest that Poloxamer has neuroprotective effects in vivo; however, at a fixed loading dose, these effects are limited to approximately 1 month post-implantation.

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Web of Science research areas
Engineering, Biomedical
Neurosciences
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