Journal article
Primary and Radiation-induced Breast Angiosarcoma Clinicopathologic Predictors of Outcomes and the Impact of Adjuvant Radiation Therapy
American journal of clinical oncology, v 39(5), pp 463-467
01 Oct 2016
PMID: 25521258
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Mammary angiosarcoma (AS) is an aggressive malignancy with high recurrence rates and poor overall survival. Limited data exist to guide treatment. We aimed to identify patterns of failure in the context of adjuvant radiation and to identify prognostic indicators to better guide management.
Methods: Thirty-five patients with breast AS at UPMC Magee Women's Hospital from June 1994 to March 2011 were retrospectively reviewed. Pathology was rereviewed for 22 patients by an expert breast pathologist using an objective scoring system, partly based on the Rosen grading scheme. All patients completed R0 resection, with 14 of them receiving adjuvant radiotherapy (RT) (82% of which represented reirradiation for radiation-induced AS).
Results: At a median follow-up of 20 months (range, 3 to 178 mo), the primary mode of failure was local with 32% local first failure. Tumor size >5 cm, radiation-induced etiology, and the omission of adjuvant RT were important prognostic factors of tumor control and survival. Histopathology including necrosis, number of mitotic figures, endothelial tufting, solid/spindle cell foci, and the combined scoring system were prognostic for recurrence patterns.
Conclusions: Breast AS has high rates of local failure despite RO resection, which may be improved with adjuvant RT, even in the reirradiation setting. Histopathology is prognostic for recurrence patterns.
Metrics
Details
- Title
- Primary and Radiation-induced Breast Angiosarcoma Clinicopathologic Predictors of Outcomes and the Impact of Adjuvant Radiation Therapy
- Creators
- Erica R. Ghareeb - Radiation Oncology AssociatesRohit Bhargava - University of PittsburghJohn A. Vargo - Radiation Oncology AssociatesAnca V. Florea - University of PittsburghSushil Beriwal - Radiation Oncology Associates
- Publication Details
- American journal of clinical oncology, v 39(5), pp 463-467
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000385339500008
- Scopus ID
- 2-s2.0-84919663196
- Other Identifier
- 991021897387704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology