Journal article
Priming for destruction: septins at the crossroads of mitochondrial fission and bacterial autophagy
EMBO reports, v 17(7), pp 935-937
Jul 2016
PMID: 27279260
Abstract
Mitochondria are essential organelles for cell survival, programmed cell death, and autophagy. They undergo cycles of fission and fusion, which are subverted by infectious pathogens and altered in many human diseases. Mitochondrial fission is mediated by the dynamin‐related protein Drp1, but the precise mechanism of its action is not well understood. In the last and current issues of
EMBO
Reports
, two new studies
1
,
2
reveal that the filamentous septin
GTP
ases interact directly with Drp1, promoting mitochondrial fission. Moreover, mitochondria were found to promote the assembly of septin filaments into cages around cytosolic
Shigella flexneri
bacteria
2
, which are targeted for autophagy. Thus, septins emerge as integral components of the machinery of mitochondrial fission and may pose a novel link between mitochondria and autophagy.
Metrics
Details
- Title
- Priming for destruction: septins at the crossroads of mitochondrial fission and bacterial autophagy
- Creators
- Elias T Spiliotis - Drexel UniversityLee Dolat - Drexel University
- Publication Details
- EMBO reports, v 17(7), pp 935-937
- Publisher
- John Wiley and Sons Inc; Hoboken
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000379337500005
- Scopus ID
- 2-s2.0-84977579804
- Other Identifier
- 991014877868504721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology