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Principles governing recruitment of motoneurons during swimming in zebrafish
Journal article   Peer reviewed

Principles governing recruitment of motoneurons during swimming in zebrafish

Jens Peter Gabriel, Jessica Ausborn, Konstantinos Ampatzis, Riyadh Mahmood, Emma Eklof-Ljunggren and Abdeljabbar El Manira
Nature neuroscience, v 14(1), pp 93-99
01 Jan 2011
DOI: https://doi.org/10.1038/nn.2704
PMID: 21113162
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1038/nn.2704View
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Abstract

Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Science & Technology
Locomotor movements are coordinated by a network of neurons that produces sequential muscle activation. Different motoneurons need to be recruited in an orderly manner to generate movement with appropriate speed and force. However, the mechanisms governing recruitment order have not been fully clarified. Using an in vitro juvenile/adult zebrafish brainstem-spinal cord preparation, we found that motoneurons were organized into four pools with specific topographic locations and were incrementally recruited to produce swimming at different frequencies. The threshold of recruitment was not dictated by the input resistance of motoneurons, but was instead set by a combination of specific biophysical properties and the strength of the synaptic currents. Our results provide insights into the cellular and synaptic computations governing recruitment of motoneurons during locomotion.

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89 citations in Web of Science
90 citations in Scopus

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