Journal article
Prior regular exercise improves clinical outcome and reduces demyelination and axonal injury in experimental autoimmune encephalomyelitis
Journal of neurochemistry, v 136 Suppl 1(S1), pp 63-73
Jan 2016
PMID: 26364732
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although previous studies have shown that forced exercise modulates inflammation and is therapeutic acutely for experimental autoimmune encephalomyelitis (EAE), the long-term benefits have not been evaluated. In this study, we investigated the effects of preconditioning exercise on the clinical and pathological progression of EAE. Female C57BL/6 mice were randomly assigned to either an exercised (Ex) or unexercised (UEx) group and all of them were induced for EAE. Mice in the Ex group had an attenuated clinical score relative to UEx mice throughout the study. At 42 dpi, flow cytometry analysis showed a significant reduction in B cells, CD4(+) T cells, and CD8(+) T cells infiltrating into the spinal cord in the Ex group compared to UEx. Ex mice also had a significant reduction in myelin damage with a corresponding increase in proteolipid protein expression. Finally, Ex mice had a significant reduction in axonal damage. Collectively, our study demonstrates for the first time that a prolonged and forced preconditioning protocol of exercise improves clinical outcome and attenuates pathological hallmarks of EAE at chronic disease. In this study, we show that a program of 6 weeks of preconditioning exercise promoted a significant reduction of cells infiltrating into the spinal cord, a significant reduction in myelin damage and a significant reduction in axonal damage in experimental autoimmune encephalomyelitis (EAE) mice at 42 dpi. Collectively, our study demonstrates for the first time that a preconditioning protocol of exercise improves clinical outcome and attenuates pathological hallmarks of EAE at chronic disease.
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Details
- Title
- Prior regular exercise improves clinical outcome and reduces demyelination and axonal injury in experimental autoimmune encephalomyelitis
- Creators
- Danielle Bernardes - The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida, USARoberta Brambilla - The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida, USAValerie Bracchi-Ricard - Drexel UniversityShaffiat Karmally - The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida, USAAnna Dellarole - The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida, USAJuliana Carvalho-Tavares - Departamento de Fisiologia e Biofísica, Núcleo de Neurociências, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilJohn R Bethea - Drexel University
- Publication Details
- Journal of neurochemistry, v 136 Suppl 1(S1), pp 63-73
- Publisher
- Wiley
- Grant note
- NS051709 / NINDS NIH HHS NS065479 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000368786400007
- Scopus ID
- 2-s2.0-84956583567
- Other Identifier
- 991019167699004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences