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Journal article
Pro-Neurotensin/Neuromedin N and Risk o f Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort
The journal of clinical endocrinology and metabolism, v 106(9), pp E3483-E3494
01 Sep 2021
PMID: 34013344
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Context: The peptide neurotensin is implicated in insulin resistance, diabetes mellitus (DM), and cardiovascular disease.
Objective: We studied the association of neurotensin's stable precursor, pro-neurotensin/neuromedin N (pro-NT/NMN) with incident metabolic syndrome (MetS) and DM.
Methods: We included 3772 participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study who completed the baseline exam (2003-2007), the follow-up exam (2013-2016), and had pro-NT/NMN measured by immunoassay. Weighted logistic regression models were fitted to incident DM, incident MetS, and each MetS component, separately, incorporating demographics, metabolic risk factors, homeostasis model of insulin resistance (HOMA-IR), and diet scores. Incident MetS was defined by 3 or more harmonized criteria at follow-up in those with fewer than 3 at baseline. Incident DM was defined by use of hypoglycemic drugs/insulin, fasting glucose 126 mg/dL or greater, or random glucose 200 mg/dL or greater in those without these at baseline.
Results: Median (IQR) plasma pro-NT/NMN was 160 pmol/L (118-218 pmol/L). A total of 564 (of 2770 without baseline MetS) participants developed MetS, and 407 (of 3030 without baseline DM) developed DM. Per SD higher log-pro-NT/NMN, the demographic-adjusted odds ratio (OR) and 95% CI of incident MetS was 1.22 (1.11-1.35), 1.16 (1.001.35) for incident low high-density lipoprotein (HDL), and 1.25 (1.11-1.40) for incident dysglycemia. The association of pro-NT/NMN with MetS was attenuated in the model adding HOMA-IR (OR per SD log-pro-NT/NMN 1.14; 95% CI, 1.00-1.30). There was no association with incident DM (OR per SD log-pro-NT/NMN 1.06; 95% CI, 0.94-1.19).
Conclusion: Pro-NT/NMN was associated with MetS and 2 components, dysglycemia and low HDL, likely explained by insulin resistance.
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Details
- Title
- Pro-Neurotensin/Neuromedin N and Risk o f Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort
- Creators
- Charles D. Nicoli - University of VermontApril P. Carson - University of Alabama at BirminghamTimothy B. Plante - University of VermontD. Leann Long - University of Alabama at BirminghamLeslie A. McClure - Drexel UniversityJanin Schulte - SphingoTec GmbH, 16761 Hennigsdorf, GermanyMary Cushman - University of Vermont
- Publication Details
- The journal of clinical endocrinology and metabolism, v 106(9), pp E3483-E3494
- Publisher
- Endocrine Soc
- Number of pages
- 12
- Grant note
- U01 NS041588 / National Institute on Aging (NIA), National Institutes of Health, Department of Health and Human Service National Institute of Neurological Disorders and Stroke (NINDS); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000692625700041
- Scopus ID
- 2-s2.0-85114034170
- Other Identifier
- 991019168528504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism