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Proarrhythmic effects of adenosine: one decade of clinical data
Journal article   Peer reviewed

Proarrhythmic effects of adenosine: one decade of clinical data

Amir Pelleg, Ronald S Pennock and Steven P Kutalek
American journal of therapeutics, v 9(2), pp 141-147
Mar 2002
DOI: https://doi.org/10.1097/00045391-200203000-00008
PMID: 11897928

Abstract

Adenosine - administration & dosage Adenosine - therapeutic use Anti-Arrhythmia Agents - administration & dosage Anti-Arrhythmia Agents - therapeutic use Arrhythmias, Cardiac - prevention & control Clinical Trials as Topic Humans Infusions, Intravenous
In 1989, adenosine was introduced into the American clinical setting as an antiarrhythmic drug for the acute management of reentrant supraventricular tachycardia involving the atrioventricular node. During this decade of use, evidence for proarrhythmic effects of the drug have been documented. In addition to the mostly benign transient episodes of atrial fibrillation, several cases of life-threatening ventricular arrhythmias induced by adenosine have been reported. This article summarizes the proarrhythmic effects of adenosine as they were reported in the literature as well as data from the manufacturer files. The causes of these adverse effects of adenosine are analyzed, and factors to be considered before using the drug are discussed.

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