Journal article
Probing spinal circuits controlling walking in mammals
Biochemical and biophysical research communications, v 396(1)
21 May 2010
PMID: 20494103
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Locomotion in mammals is a complex motor act that involves the activation of a large number of muscles in a well-coordinated pattern. Understanding the network organization of the intrinsic spinal networks that control the locomotion, the central pattern generators, has been a challenge to neuroscientists. However, experiments using the isolated rodent spinal cord and combining electrophysiology and molecular genetics to dissect the locomotor network have started to shed new light on the network structure. In the present review, we will discuss findings that have revealed the role of designated populations of neurons for the key network functions including coordinating muscle activity and generating rhythmic activity. These findings are summarized in proposed organizational principles for the mammalian segmental CPG. (C) 2010 Elsevier Inc. All rights reserved.
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Details
- Title
- Probing spinal circuits controlling walking in mammals
- Creators
- Ole Kiehn - Karolinska InstitutetKimberly J. Dougherty - Karolinska InstitutetMartin Haegglund - Karolinska InstitutetLotta Borgius - Karolinska InstitutetAdolfo Talpalar - Karolinska InstitutetCarlos Ernesto Restrepo - Karolinska Institutet
- Publication Details
- Biochemical and biophysical research communications, v 396(1)
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- Friends of Karolinska Institutet Swedish Medical Research Council; Swedish Medical Research Council (SMRC) European Union (SPINAL CORD REPAIR); European Commission Soderbergs Foundation R01NS040795-09 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01NS040795 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000278251800004
- Scopus ID
- 2-s2.0-77952316652
- Other Identifier
- 991020100204104721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics