Journal article
Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
The Journal of clinical investigation, v 123(2), pp 903-907
01 Feb 2013
PMID: 23321668
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SW-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4(+) T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.
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Details
- Title
- Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
- Creators
- Nichole R. Klatt - National Institutes of HealthLauren A. Canary - National Institutes of HealthXiaoyong Sun - Vaccine & Gene Therapy Institute of FloridaCarol L. Vinton - National Institutes of HealthNicholas T. Funderburg - Case Western Reserve UniversityDavid R. Morcock - Science Applications International Corporation (United States)Mariam Quinones - National Institutes of HealthClayton B. Deming - National Institutes of HealthMolly Perkins - National Institutes of HealthDaria J. Hazuda - MERCKMichael D. Miller - Gilead Sci Inc, Foster City, CA 94404 USAMichael M. Lederman - Case Western Reserve UniversityJulie A. Segre - National Institutes of HealthJeffrey D. Lifson - Science Applications International Corporation (United States)Elias K. Haddad - Vaccine & Gene Therapy Institute of FloridaJacob D. Estes - Science Applications International Corporation (United States)Jason M. Brenchley - National Institutes of Health
- Publication Details
- The Journal of clinical investigation, v 123(2), pp 903-907
- Publisher
- Amer Soc Clinical Investigation Inc
- Number of pages
- 5
- Grant note
- ZIAAI001194 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) HHSN261200800001E / National Cancer Institute (NCI)/NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Intramural NIAID, US NIH program ZIAHG000180 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000314553600042
- Scopus ID
- 2-s2.0-84873369889
- Other Identifier
- 991020100188904721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental