Journal article
Probiotics: insights and new opportunities for Clostridioides difficile intervention
Critical reviews in microbiology, v 49(3), pp 414-434
04 May 2023
PMID: 35574602
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Clostridioides difficile infection (CDI) is a life-threatening disease caused by the Gram-positive, opportunistic intestinal pathogen C. difficile. Despite the availability of antimicrobial drugs to treat CDI, such as vancomycin, metronidazole, and fidaxomicin, recurrence of infection remains a significant clinical challenge. The use of live commensal microorganisms, or probiotics, is one of the most investigated non-antibiotic therapeutic options to balance gastrointestinal (GI) microbiota and subsequently tackle dysbiosis. In this review, we will discuss major commensal probiotic strains that have the potential to prevent and/or treat CDI and its recurrence, reassess the efficacy of probiotics supplementation as a CDI intervention, delve into lessons learned from probiotic modulation of the immune system, explore avenues like genome-scale metabolic network reconstructions, genome sequencing, and multi-omics to identify novel strains and understand their functionality, and discuss the current regulatory framework, challenges, and future directions.
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Details
- Title
- Probiotics: insights and new opportunities for Clostridioides difficile intervention
- Creators
- Rusha Pal - University of VirginiaAhmad I. M. Athamneh - College Station Medical CenterRiddhi Deshpande - Reading Hosp, Tower Hlth, W Reading, PA USAJose A. R. Ramirez - James Cook UniversityKayode T. Adu - James Cook UniversityPushpanathan Muthuirulan - Harvard UniversityShrikant Pawar - College Station Medical CenterManuele Biazzo - Bioarte Ltd Labs, Life Sci Pk, San Gwann, MaltaYiorgos Apidianakis - University of CyprusUlrik Kraemer Sundekilde - Aarhus UniversityCesar de la Fuente-Nunez - College Station Medical CenterMark G. Martens - Reading Hosp, Tower Hlth, W Reading, PA USAGeorge P. Tegos - Drexel Univ, Coll Med, Philadelphia, PA 19104 USAMohamed N. Seleem - University of Virginia
- Publication Details
- Critical reviews in microbiology, v 49(3), pp 414-434
- Publisher
- Taylor & Francis
- Number of pages
- 21
- Grant note
- R01AI148523; R01AI130186 / National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01AI130186 / National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000795777500001
- Scopus ID
- 2-s2.0-85130443331
- Other Identifier
- 991022207157504721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Microbiology