Journal article
Problems and progress in the diagnosis and treatment of polydipsia and hyponatremia
Schizophrenia bulletin, v 22(3), pp 455-464
01 Jan 1996
PMID: 8873296
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Abstract
Fluid-electrolyte balance is regulated within a narrow range and disturbances in this system are unusual in animals and humans. Studies from the preneuroleptic era to date suggest that up to 25% of patients with schizophrenia have polydipsia (PD), suggesting that it is related to the pathophysiology of the psychoses. PD and the related phenomenon of hyponatremia cause considerable mortality and morbidity. Prevalence studies are limited by imprecise measures available at present. The treatment was limiting water intake when patients reached critical levels of water retention, which however did not improve PD. Recent case reports and open studies have shown that clozapine improves both PD and water retention. The response occurs at low doses and is not related to improvement in psychosis. This may not be applicable to all patients and better understanding of the pathophysiology of PD-hyponatremia would lead to more empirically derived treatments. (PsycInfo Database Record (c) 2020 APA, all rights reserved)
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Details
- Title
- Problems and progress in the diagnosis and treatment of polydipsia and hyponatremia
- Creators
- Cherian Verghese - Drexel UniversityJosé de LeonRichard C Josiassen - Drexel University
- Publication Details
- Schizophrenia bulletin, v 22(3), pp 455-464
- Publisher
- National Institute of Mental Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:A1996VE21700006
- Scopus ID
- 2-s2.0-0029813362
- Other Identifier
- 991019167716404721
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- Web of Science research areas
- Psychiatry