Journal article
Profound Bias in Interferon-γ and Interleukin-6 Allele Frequencies in Western Kenya, Where Severe Malarial Anemia Is Common in Children
The Journal of infectious diseases, v 186(7), pp 1007-1012
01 Oct 2002
PMID: 12232842
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The intensity of malaria transmission is related to the pattern of malarial disease observed in different regions, but populations may also differ in their underlying predispositions to severe malarial anemia or cerebral malaria. In western Kenya, where severe malarial anemia is much more common than cerebral malaria, the distributions of tumor necrosis factor (TNF)–α, interleukin (IL)–10, transforming growth factor (TGF)–β, IL-6, and interferon (IFN)–γ alleles were examined in a cohort of young men. The cohort displayed a marked bias toward genotypes associated with low expression of IFN-γ and IL-6, cytokines that, at high levels, have been implicated in malarial anemia and poor malaria outcomes. By contrast, the frequency of the TNF-α −238A allele, which has been associated with severe malarial anemia, was found to be similar to the frequency previously reported in comparison populations in Africa and elsewhere. IFN-γ and IL-6 genotypes may play roles in the development of severe malaria and could contribute to the relative frequency of severe malarial anemia or cerebral malaria in exposed populations
Metrics
Details
- Title
- Profound Bias in Interferon-γ and Interleukin-6 Allele Frequencies in Western Kenya, Where Severe Malarial Anemia Is Common in Children
- Creators
- Ian S. Gourley - Hospital of the University of PennsylvaniaJonathan D. Kurtis - Hospital of the University of PennsylvaniaMalek Kamoun - Hospital of the University of PennsylvaniaJoseph J. Amon - Uniformed Services University of the Health SciencesPatrick E. Duffy - Walter Reed Army Institute of Research
- Publication Details
- The Journal of infectious diseases, v 186(7), pp 1007-1012
- Publisher
- The University of Chicago Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Community Health and Prevention
- Web of Science ID
- WOS:000177991100016
- Scopus ID
- 2-s2.0-0036786903
- Other Identifier
- 991021895666604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology