Journal article
Progesterone enhances inhibitory responses of cerebellar Purkinje cells mediated by the GABA A receptor subtype
Brain research bulletin, v 23(4), pp 317-322
1989
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previous studies from this laboratory have indicated that the sex steroid progesterone (P) is able to augment inhibitory responses of cerebellar Purkinje cells to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the urethane anesthetized adult female rat. Because both GABA
A and GABA
B receptors are localized in this CNS area, agonist/antagonists for these receptors were utilized in the present evaluation in order to delineate the specific receptor subtype involved in P-GABA interactions. Systemically administered P was found to augment GABA-mediated inhibition by an average of 80%. Concomitant application of the GABA
A blocker, bicuculline, greatly reduced this modulatory effect of the steroid. In contrast, P administration had no effect on baclofen-induced inhibition. These data suggest that P effects on GABA physiology are mediated predominantly at the GABA
A receptor.
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Details
- Title
- Progesterone enhances inhibitory responses of cerebellar Purkinje cells mediated by the GABA A receptor subtype
- Creators
- Sheryl S. Smith - Hahnemann University HospitalSusan S Smith - [Retired Faculty]
- Publication Details
- Brain research bulletin, v 23(4), pp 317-322
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1989CD20700010
- Scopus ID
- 2-s2.0-0024368604
- Other Identifier
- 991019183938704721
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- Web of Science research areas
- Neurosciences