Journal article
Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections
Current opinion in HIV & AIDS, v 2(3), pp 219-227
01 May 2007
PMID: 19372890
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose of review
The intricate balance between positive and negative signals delivered by accessory molecules is crucial to generate efficient immune responses while maintaining tolerance and preventing autoimmunity. Of these molecules, programmed death 1 has been described as a negative regulator of T-cell activation. This review will focus on current knowledge about PD-1 regulation in different diseases and discuss its potential benefits for the development of novel immune therapies.
Recent findings
PD-1 has recently been shown to be upregulated on HIV-specific CD8 T cells, whereas the PD-1 expression level was significantly correlated with viral load. Blockade of the PD-1/PD-L1 interaction enhanced the capacity of HIV-specific CD8 and CD4 T cells to proliferate or secrete cytokines and cytotoxic molecules. Future manipulations of this pathway could rescue the function of exhausted CD8 and CD4 T cells.
Summary
The engagement of PD-1 with its ligands induces inhibitory signals as it blocks T-cell receptor-induced T-cell proliferation and cytokine production. The PD-1 pathway plays a crucial role in the maintenance of peripheral tolerance and the pathogenesis of cancer and chronic viral infections. Understanding the mechanisms by which PD-1 interferes with T-cell functions will pave the way for novel therapeutic immune interventions to treat these diseases.
Metrics
Details
- Title
- Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections
- Creators
- Lydie Trautmann - McGill UniversityElias A. Said - Czech Academy of Sciences, Institute of MicrobiologyRabih Halwani - Université de MontréalLoury Janbazian - McGill UniversityNicolas Chomont - Université de MontréalMohamed El-Far - Université de MontréalGaelle Breton - Université de MontréalElias K. Haddad - Ctr Rech CHUM St Luc, Lab Immunol, Montreal, PQ, CanadaRafick-Pierre Sekaly - McGill University
- Publication Details
- Current opinion in HIV & AIDS, v 2(3), pp 219-227
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Grant note
- Genome Quebec National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Canadian Network for Vaccine and Immunotherapeutics Genome Canada Valorisation Recherche Quebec Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000208417800009
- Scopus ID
- 2-s2.0-34250662666
- Other Identifier
- 991020099926404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases