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Journal article
Programmed death-1-induced interleukin-10 production by monocytes impairs CD4(+) T cell activation during HIV infection
Nature medicine, v 16(4), pp 452-U136
01 Apr 2010
PMID: 20208540
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4(+) T cell numbers during HIV infection. Programmed death-1 (PD-1) and interleukin-10 (IL-10) are both upregulated during HIV infection. Blocking interactions between PD-1 and programmed death ligand-1 (PD-L1) and between IL-10 and IL-10 receptor (IL-10R) results in viral clearance and improves T cell function in animal models of chronic viral infections. Here we show that high amounts of microbial products and inflammatory cytokines in the plasma of HIV-infected subjects lead to upregulation of PD-1 expression on monocytes that correlates with high plasma concentrations of IL-10. Triggering of PD-1 expressed on monocytes by PD-L1 expressed on various cell types induced IL-10 production and led to reversible CD4(+) T cell dysfunction. We describe a new function for PD-1 whereby microbial products inhibit T cell expansion and function by upregulating PD-1 levels and IL-10 production by monocytes after binding of PD-1 by PD-L1.
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Details
- Title
- Programmed death-1-induced interleukin-10 production by monocytes impairs CD4(+) T cell activation during HIV infection
- Creators
- Elias A. Said - Université de MontréalFranck P. Dupuy - Université de MontréalLydie Trautmann - Centre Hospitalier de l’Université de MontréalYuwei Zhang - Université de MontréalYu Shi - Université de MontréalMohamed El-Far - Université de MontréalBrenna J. Hill - National Institutes of HealthAlessandra Noto - Université de MontréalPetronela Ancuta - Université de MontréalYoav Peretz - Université de MontréalSimone G. Fonseca - Université de MontréalJulien Van Grevenynghe - Université de MontréalMohamed R. Boulassel - McGill University Health CentreJulie Bruneau - Université de MontréalNaglaa H. Shoukry - Université de MontréalJean-Pierre Routy - McGill UniversityDaniel C. Douek - National Institutes of HealthElias K. Haddad - CRCHUM, Hop St Luc, Montreal, PQ, CanadaRafick-Pierre Sekaly - Centre Hospitalier de l’Université de Montréal
- Publication Details
- Nature medicine, v 16(4), pp 452-U136
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- Canadian Foundation for AIDS Research Fonds de la recherche en sante du Quebec; Fonds de la Recherche en Sante du Quebec Canadian Institutes of Health Research (CIHR) US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Canadian Foundation for Infectious Diseases Canadian Network for Vaccines and Immunotherapeutics ZIAAI005033 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000276446800050
- Scopus ID
- 2-s2.0-77950525439
- Other Identifier
- 991020099169804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Medicine, Research & Experimental