Journal article
Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward
Clinical cancer research, v 12(12), pp 3661-3697
15 Jun 2006
PMID: 16778094
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This article reviews progress in chemopreventive drug development, especially data and concepts that are new since the 2002 AACR report on treatment and prevention of intraepithelial neoplasia. Molecular biomarker expressions involved in mechanisms of carcinogenesis and genetic progression models of intraepithelial neoplasia are discussed and analyzed for how they can inform mechanism-based, molecularly targeted drug development as well as risk stratification, cohort selection, and end-point selection for clinical trials. We outline the concept of augmenting the risk, mechanistic, and disease data from histopathologic intraepithelial neoplasia assessments with molecular biomarker data. Updates of work in 10 clinical target organ sites include new data on molecular progression, significant completed trials, new agents of interest, and promising directions for future clinical studies. This overview concludes with strategies for accelerating chemopreventive drug development, such as integrating the best science into chemopreventive strategies and regulatory policy, providing incentives for industry to accelerate preventive drugs, fostering multisector cooperation in sharing clinical samples and data, and creating public-private partnerships to foster new regulatory policies and public education.
Metrics
Details
- Title
- Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward
- Creators
- Gary J Kelloff - National Institutes of HealthScott M Lippman - The University of Texas MD Anderson Cancer CenterAndrew J Dannenberg - Cornell UniversityCaroline C Sigman - CCS Associates (United States)Homer L Pearce - ELI LILLYBrian J Reid - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaEva Szabo - National Institutes of HealthV Craig Jordan - Fox Chase Cancer CenterMargaret R Spitz - The University of Texas MD Anderson Cancer CenterGordon B Mills - The University of Texas MD Anderson Cancer CenterVali A Papadimitrakopoulou - The University of Texas MD Anderson Cancer CenterReuben Lotan - The University of Texas MD Anderson Cancer CenterBharat B Aggarwal - The University of Texas MD Anderson Cancer CenterRobert S Bresalier - The University of Texas MD Anderson Cancer CenterJeri Kim - The University of Texas MD Anderson Cancer CenterBanu Arun - The University of Texas MD Anderson Cancer CenterKaren H Lu - The University of Texas MD Anderson Cancer CenterMelanie E ThomasHelen E Rhodes - The University of Texas MD Anderson Cancer CenterMolly A Brewer - University of ArizonaMichele Follen - The University of Texas MD Anderson Cancer CenterDong M Shin - Emory UniversityHoward L Parnes - National Institutes of HealthJill M Siegfried - University of PittsburghAlison A Evans - Fox Chase Cancer CenterWilliam J Blot - International Epidemiology InstituteWong-Ho Chow - National Institutes of HealthPatricia L Blount - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaCarlo C Maley - The Wistar InstituteKenneth K Wang - Mayo Clinic in ArizonaStephen Lam - University of British ColumbiaJ Jack LeeSteven M Dubinett - University of California, Los AngelesPaul F Engstrom - Fox Chase Cancer CenterFrank L Meyskens - University of California, IrvineJoyce O'Shaughnessy - Texas OncologyErnest T Hawk - National Institutes of HealthBernard Levin - The University of Texas MD Anderson Cancer CenterWilliam G Nelson - Johns Hopkins UniversityWaun Ki Hong - The University of Texas MD Anderson Cancer CenterAACR Task Force Canc Prevention
- Publication Details
- Clinical cancer research, v 12(12), pp 3661-3697
- Publisher
- American Association for Cancer Research (AACR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000238415100006
- Scopus ID
- 2-s2.0-33745683516
- Other Identifier
- 991020640688304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology