Journal article
Progression of molecular mechanisms controlling self-renewal and differentiation of embryonic stem cells or induced pluripotent stem cells
Shanghai jiao tong da xue xue bao. Yi xue ban, v 32(9), pp 1166-1170
01 Sep 2012
Abstract
During 2008 to 2011, affiliated project of genetic development and reproductive medicine key discipline-- research project on molecular mechanisms controlling self-renewal and differentiation of embryonic stem cells or induced pluripotent stem cells, which was funded by 211 Project at the third stage, had gained many results, including establishment of the profiling of human embryos during early organogenesis: discovery of calcineurin-NFAT signaling critically regulating early lineage specification in mouse embryonic stem cells and embryos. Moreover, the regulatory mechanism of Oct4-centered core transcriptional circuitry for ES cell fate decision is elucidated: investigating the posttranslational modification of key transcription factor Oct4: discovering PARP1 Poly(ADP-ribosyl) ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation: finding that coactivator p300 in mouse embryonic stem cell differentiation and nanog expression have critical roles: demonstratin
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Details
- Title
- Progression of molecular mechanisms controlling self-renewal and differentiation of embryonic stem cells or induced pluripotent stem cells
- Creators
- Y JinX-H RenX-F Liu
- Publication Details
- Shanghai jiao tong da xue xue bao. Yi xue ban, v 32(9), pp 1166-1170
- Resource Type
- Journal article
- Language
- Chinese
- Academic Unit
- Neurobiology and Anatomy
- Scopus ID
- 2-s2.0-84868222841
- Other Identifier
- 991020545224304721