Journal article
Projection microfabrication of three-dimensional scaffolds for tissue engineering
Journal of manufacturing science and engineering, v 130(2), pp 0210051-0210054
01 Apr 2008
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This article presents a micromanufacturing method for direct projection printing of three-dimensional scaffolds for applications in the field of tissue engineering by using a digital micromirror-array device (DMD) in a layer-by-layer process. Multilayered scaffolds are microfabricated using curable materials through an ultraviolet (UV) photopolymerization process. The prepatterned UV light is projected onto the photocurable polymer solution by creating the "photomask" design with a graphic software. Poly(ethylene glycol) diacrylate is mixed with a small amount of dye (0.3 wt %) to enhance the fabrication resolution of the scaffold. The DMD fabrication system is equipped with a purging mechanism to prevent the accumulation of oligomer which could interfere with the feature resolution of previously polymerized layers. The surfaces of the predesigned multilayered scaffold are covalently conjugated with fibronectin for efficient cellular attachment. Our results show that murine marrow-derived progenitor cells successfully attached to fibronectin-modified scaffolds.
Metrics
Details
- Title
- Projection microfabrication of three-dimensional scaffolds for tissue engineering
- Creators
- Li-Hsin Han - Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USAGazell Mapili - The University of Texas at AustinShaochen Chen - The University of Texas at AustinKrishnendu Roy - The University of Texas at Austin
- Publication Details
- Journal of manufacturing science and engineering, v 130(2), pp 0210051-0210054
- Publisher
- Asme
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000255846300006
- Scopus ID
- 2-s2.0-47049111390
- Other Identifier
- 991020545227404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Manufacturing
- Engineering, Mechanical