Journal article
Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures
Neuroscience, v 114(1), pp 229-238
2002
PMID: 12207968
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prolactin releasing peptide (PrRP) is a recently identified neuropeptide that stimulates prolactin release from pituitary cells. The presence of its receptor outside the hypothalamic-pituitary axis suggests that it may have other functions. We present here evidence that PrRP can modulate the activity of the reticular thalamic nucleus, a brain region with prominent PrRP receptor expression that is critical for sleep regulation and the formation of non-convulsive absence seizures. Intracerebroventricular injection of PrRP (1–10 nmol) into sleeping animals significantly suppresses sleep oscillations and promotes rapid and prolonged awakening. Higher concentrations of PrRP (10–100 nmol) similarly suppress spike wave discharges seen during absence seizures in genetic absence epilepsy rats from Strasbourg, an animal model for this disorder. In concordance with these findings, PrRP suppressed evoked oscillatory burst activity in reticular thalamic slices
in vitro.
These results indicate that PrRP modulates reticular thalamic function and that activation of its receptor provides a new target for therapies directed at sleep disorders and absence seizures.
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Details
- Title
- Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures
- Creators
- S.H.S Lin - Department of Pharmacology, University of California, Irvine, Med Surge II, Room 369, Irvine, CA 92697-4855, USAA.C Arai - Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USAR.A España - Psychology Department, University of Wisconsin, Madison, WI 53706, USAC.W Berridge - Psychology Department, University of Wisconsin, Madison, WI 53706, USAF.M Leslie - Department of Pharmacology, University of California, Irvine, Med Surge II, Room 369, Irvine, CA 92697-4855, USAJ.R Huguenard - Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USAM Vergnes - INSERM U398, Faculté de Médecine, F-67085 Strasbourg, FranceO Civelli - Department of Pharmacology, University of California, Irvine, Med Surge II, Room 369, Irvine, CA 92697-4855, USA
- Publication Details
- Neuroscience, v 114(1), pp 229-238
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000178011200021
- Scopus ID
- 2-s2.0-0037130579
- Other Identifier
- 991014878293804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences