Journal article
Prolonged E55+ Retrovirus Expression in Aged Mice Is Associated with a Decline in the Anti-Virus Immune Response
Virology (New York, N.Y.), v 290(2), pp 281-289
25 Nov 2001
PMID: 11883192
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
E55+ murine leukemia retrovirus (E55+MuLV) infection of young and aged C57BL/6 (B6) mice was used to investigate the relationship between increased incidences of infection and decreased immune responsiveness of elderly individuals. Young mice decreased E55+MuLV burden to below detectable levels by 8 weeks postinfection (p.i.). In contrast, virus burden in aged mice did not reach undetectable levels until 20 weeks p.i. A significant T cell proliferative response to E55+MuLV was detected from 2 to 12 weeks p.i. in young mice, but was never observed in aged mice. Both age groups demonstrated significant E55+MuLV-specific T-cell-mediated cytotoxic responses at 3 and 4 weeks p.i. and virus neutralizing antibody titers at 2, 4, 8, and 12 weeks p.i. In both cases, responses were consistently higher in young mice (P < 0.04 and P < 0.02, respectively). These results demonstrate that the observed delay in E55+MuLV clearance by aged mice is associated with an age-related decrease in the immune response to the virus.
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Details
- Title
- Prolonged E55+ Retrovirus Expression in Aged Mice Is Associated with a Decline in the Anti-Virus Immune Response
- Creators
- Mohamed ElRefaei - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, 19129Kenneth J Blank - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, 19129Donna M Murasko - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, 19129
- Publication Details
- Virology (New York, N.Y.), v 290(2), pp 281-289
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000172753500011
- Scopus ID
- 2-s2.0-0035950923
- Other Identifier
- 991014877940704721
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- Web of Science research areas
- Virology