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Prolonged akinetic mutism due to multiple sclerosis
Journal article   Peer reviewed

Prolonged akinetic mutism due to multiple sclerosis

T F Scott, D Lang, R M Girgis and T Price
The journal of neuropsychiatry and clinical neurosciences, v 7(1)
1995
PMID: 7711499

Abstract

Adult Akinetic Mutism - etiology Akinetic Mutism - pathology Akinetic Mutism - psychology Brain - physiopathology Electroencephalography Female Humans Magnetic Resonance Imaging Multiple Sclerosis - complications Neuropsychological Tests Tomography, Emission-Computed, Single-Photon
A 25-year-old woman with multiple sclerosis and an affective disorder probably secondary to MS presented with multiple neurological signs and symptoms suggestive of active MS, most prominently akinetic mutism. Spinal fluid analysis and MRI supported a diagnosis of active MS. SPECT and EEG were nonspecifically abnormal. After 6 weeks of severe akinetic mutism refractory to one ECT treatment and trials of steroids and stimulants, the patient recovered spontaneously over a 2-month period. An acute brainstem lesion seen on MRI may explain this patient's akinetic mutism.

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Web of Science research areas
Clinical Neurology
Neurosciences
Psychiatry
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