Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Properties of mouse spinal lamina I GABAergic interneurons
Journal of neurophysiology, v 94(5), pp 3221-3227
01 Nov 2005
PMID: 16014799
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Lamina I is a sensory relay region containing projection cells and local interneurons involved in thermal and nociceptive signaling. These neurons differ in morphology, sensory response modality, and firing characteristics. We examined intrinsic properties of mouse lamina I GABAergic neurons expressing enhanced green fluorescent protein (EGFP). GABAergic neuron identity was confirmed by a high correspondence between GABA immunolabeling and EGFP fluorescence. Morphologies of these EGFP+/GABA+ cells were multipolar (65%), fusiform (31%), and pyramidal (4%). In whole cell recordings, cells fired a single spike (44%), tonically (35%), or an initial burst (21%) in response to current steps, representing a subset of reported lamina I firing properties. Membrane properties of tonic and initial burst cells were indistinguishable and these neurons may represent one functional population because, in individual neurons, their firing patterns could interconvert. Single spike cells were less excitable with lower membrane resistivity and higher rheobase. Most fusiform cells (64%) fired tonically while most multipolar cells (56%) fired single spikes. In summary, lamina I inhibitory interneurons are functionally divisible into at least two major groups both of which presumably function to limit excitatory transmission.
Metrics
Details
- Title
- Properties of mouse spinal lamina I GABAergic interneurons
- Creators
- Kimberly J Dougherty - Emory UniversityMichael A SawchukShawn Hochman
- Publication Details
- Journal of neurophysiology, v 94(5), pp 3221-3227
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000232528900023
- Scopus ID
- 2-s2.0-27144512469
- Other Identifier
- 991020100053804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Physiology