Journal article
Prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia for Cesarean section: a randomized, double-blinded, placebo-controlled prospective trial with heart rate variability correlation
Journal of clinical anesthesia, v 23(5), pp 361-366
2011
PMID: 21632228
Abstract
To determine if prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia.
Prospective, randomized, double-blinded, placebo-controlled study.
Large university-affiliated community hospital.
81 consecutive term parturients (not in active labor) who were scheduled for elective Cesarean section.
Parturients received 1.0 to 1.5 L of intravenous Ringer's lactate and either glycopyrrolate 0.4 mg or an equal volume of saline, with caregivers blinded to the immediate sequelae of study drug. Each patient received intrathecal bupivacaine (12 to 14 mg) with morphine sulfate (0.1 to 0.2 mg).
Continuous heart rate (HR) and blood pressure monitoring occurred for 20 minutes, with the minimum HR recorded for each 5-minute epoch. Heart rates < 60 beats per minute defined bradycardia. Heart rate variability (HRV) analysis occurred offline.
None of 34 patients administered glycopyrrolate and 6 of 35 (17%) patients receiving saline experienced bradycardia (
P = 0.02476). Time domain, frequency domain, and nonlinear and embedded spectrum entropy analyses all reflected the decrease in HRV accompanying administration of glycopyrrolate.
Bradycardia after spinal anesthesia occurs commonly. Prophylactic glycopyrrolate may prevent the bradycardia, but not necessarily the hypotension.
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Details
- Title
- Prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia for Cesarean section: a randomized, double-blinded, placebo-controlled prospective trial with heart rate variability correlation
- Creators
- Dmitri Chamchad - Drexel UniversityJay C. Horrow - Drexel UniversityLev Nakhamchik - Independent Consultant, Toronto, Ontario, CanadaJohn Sauter - Lankenau Institute for Medical ResearchNancy Roberts - Lankenau Institute for Medical ResearchBoris Aronzon - Lankenau Institute for Medical ResearchAndrew Gerson - Lankenau Institute for Medical ResearchMikhail Medved - Lankenau Institute for Medical Research
- Publication Details
- Journal of clinical anesthesia, v 23(5), pp 361-366
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Anesthesiology and Perioperative Medicine
- Web of Science ID
- WOS:000293940000003
- Scopus ID
- 2-s2.0-79960935375
- Other Identifier
- 991019168698704721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Anesthesiology