Journal article
Prophylactic tranexamic acid decreases bleeding after cardiac operations
The Journal of thoracic and cardiovascular surgery, v 99(1), pp 70-74
Jan 1990
PMID: 2403616
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Thirty-eight patients undergoing a cardiac operation randomly received either tranexamic acid, a potent inhibitor of plasminogen, or placebo in an effort to determine whether prophylactic antifibrinolytic therapy reduces chest tube drainage. Twelve-hour blood loss was 750 +/- 314 (standard deviation) ml in the placebo group and 496 +/- 228 ml in the drug group (p = 0.0057). Fibrin split products were present more frequently in patients in the placebo group (17 of 20 compared with four of 18 in the drug group; p = 0.0002). Tranexamic acid markedly decreased plasminogen availability (112 +/- 104 units in the placebo group versus 36 +/- 18 units in the drug group, p = 0.0058). Plasma fibrinogen concentrations were similar in the placebo and drug groups. Patients in the placebo group received more fresh-frozen plasma and more mediastinal shed blood than those in the drug group. No coagulation-related complication occurred in the group receiving tranexamic acid. We conclude that prophylactic tranexamic acid can be administered safely to inhibit fibrinolysis during cardiac operations, decrease postoperative bleeding, and possibly decrease the frequency of blood product transfusion.
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Details
- Title
- Prophylactic tranexamic acid decreases bleeding after cardiac operations
- Creators
- J C Horrow - Hahnemann University HospitalJ Hlavacek - Hahnemann University HospitalM D Strong - Hahnemann University HospitalW Collier - Hahnemann University HospitalI Brodsky - Hahnemann University HospitalS M Goldman - Hahnemann University HospitalI P Goel - Hahnemann University Hospital
- Publication Details
- The Journal of thoracic and cardiovascular surgery, v 99(1), pp 70-74
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Anesthesiology and Perioperative Medicine
- Web of Science ID
- WOS:A1990CH73800011
- Scopus ID
- 2-s2.0-0025141363
- Other Identifier
- 991019183970504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery