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Propionibacterium endocarditis: a case series from the International Collaboration on Endocarditis Merged Database and Prospective Cohort Study
Journal article

Propionibacterium endocarditis: a case series from the International Collaboration on Endocarditis Merged Database and Prospective Cohort Study

Tahaniyat Lalani, Anna K Person, Susan S Hedayati, Laura Moore, David R Murdoch, Bruno Hoen, Gail Peterson, Hasan Shahbaz, Didier Raoult, Jose M Miro, …
Scandinavian journal of infectious diseases, v 39(10), pp 840-848
2007
DOI: https://doi.org/10.1080/00365540701367793
PMID: 17852887
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Actinomycetales Infections - complications Actinomycetales Infections - epidemiology Actinomycetales Infections - microbiology Actinomycetales Infections - physiopathology Adult Aged Cohort Studies Databases, Factual Endocarditis, Bacterial - complications Endocarditis, Bacterial - epidemiology Endocarditis, Bacterial - microbiology Endocarditis, Bacterial - physiopathology Female Heart Diseases - complications Heart Diseases - congenital Heart Diseases - epidemiology Heart Diseases - microbiology Heart Valve Prosthesis - microbiology Humans International Cooperation Male Middle Aged Prognosis Propionibacterium - classification Propionibacterium - isolation & purification Prospective Studies Prosthesis-Related Infections - complications Prosthesis-Related Infections - epidemiology Prosthesis-Related Infections - microbiology Prosthesis-Related Infections - physiopathology Risk Factors Survival Rate
Propionibacterium species are occasionally associated with serious systemic infections such as infective endocarditis. In this study, we examined the clinical features, complications and outcome of 15 patients with Propionibacterium endocarditis using the International Collaboration on Endocarditis Merged Database (ICE-MD) and Prospective Cohort Study (ICE-PCS), and compared the results to 28 cases previously reported in the literature. In the ICE database, 11 of 15 patients were male with a mean age of 52 y. Prosthetic valve endocarditis occurred in 13 of 15 cases and 3 patients had a history of congenital heart disease. Clinical findings included valvular vegetations (9 patients), cardiac abscesses (3 patients), congestive heart failure (2 patients), and central nervous system emboli (2 patients). Most patients were treated with beta-lactam antibiotics alone or in combination for 4 to 6 weeks. 10 of the 15 patients underwent valve replacement surgery and 2 patients died. Similar findings were noted on review of the literature. The results of this paper suggest that risk factors for Propionibacterium endocarditis include male gender, presence of prosthetic valves and congenital heart disease. The clinical course is characterized by complications such as valvular dehiscence, cardiac abscesses and congestive heart failure. Treatment may require a combination of medical and surgical therapy.

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Infectious Diseases
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