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Journal article
Prospective, Multicenter, Randomized, Crossover Clinical Trial Comparing the Safety and Effectiveness of Cooled Radiofrequency Ablation With Corticosteroid Injection in the Management of Knee Pain From Osteoarthritis
Regional anesthesia and pain medicine, v 43(1), pp 84-91
Jan 2018
PMID: 29095245
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Objectives: Osteoarthritis (OA) of the knee affects the aging population and has an associated influence on the health care system. Rigorous studies evaluating radiofrequency ablation for OA-related knee pain are lacking. This study compared long-termclinical safety and effectiveness of cooled radiofrequency ablation (CRFA) with intra-articular steroid (IAS) injection in managing OA-related knee pain.
Methods: This is a prospective, multicenter, randomized trial with 151 subjects with chronic (>= 6 months) knee pain that was unresponsive to conservative modalities. Knee pain (Numeric Rating Scale [NRS]), Oxford Knee Score, overall treatment effect (Global Perceived Effect), analgesic drug use, and adverse events were compared between CRFA and IAS cohorts at 1, 3, and 6 months after intervention.
Results: There were no differences in demographics between study groups. At 6 months, the CRFA group had more favorable outcomes in NRS: pain reduction 50% or greater: 74.1% versus 16.2%, P < 0.0001 (25.9% and 83.8% of these study cohorts, respectively, were nonresponders). Mean NRS score reduction was 4.9 +/- 2.4 versus 1.3 +/- 2.2, P < 0.0001; mean Oxford Knee Score was 35.7 +/- 8.8 vs 22.4 +/- 8.5, P < 0.0001; mean improved Global Perceived Effect was 91.4% vs 23.9%, P < 0.0001; and mean change in nonopioid medication use was CRFA > IAS (P = 0.02). There were no procedure-related serious adverse events.
Conclusions: This study demonstrates that CRFA is an effective long-term therapeutic option for managing pain and improving physical function and quality of life for patients with painful knee OA when compared with IAS injection.
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Details
- Title
- Prospective, Multicenter, Randomized, Crossover Clinical Trial Comparing the Safety and Effectiveness of Cooled Radiofrequency Ablation With Corticosteroid Injection in the Management of Knee Pain From Osteoarthritis
- Creators
- Tim Davis - Orthoped Pain Specialists, Santa Monica, CA USAEric Loudermilk - Piedmont Comprehens Pain Management Grp, Greenville, SC USAMichael DePalma - Virginia Spine Research InstituteCorey Hunter - Ainsworth Inst Pain, New York, NY USADavid Lindley - Pain Management InstituteNilesh Patel - Adv Pain Management, Greenfield, WI USADaniel Choi - Arizona Pain SpecialistsMarc Soloman - Valley Anesthesia Consultants, Phoenix, AZ USAAnita Gupta - Drexel UniversityMehul Desai - International Spine, Pain & PerformanceAsokumar Buvanendran - Rush Univ, Med Ctr, Dept Anesthesiol, Chicago, IL 60612 USALeonardo Kapural - Carolinas Pain Institute
- Publication Details
- Regional anesthesia and pain medicine, v 43(1), pp 84-91
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- Halyard Health, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Anesthesiology and Perioperative Medicine
- Web of Science ID
- WOS:000428940900014
- Scopus ID
- 2-s2.0-85040071130
- Other Identifier
- 991021879915104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Anesthesiology