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Journal article
Prospective Study of Particulate Air Pollution Exposures, Subclinical Atherosclerosis, and Clinical Cardiovascular Disease The Multi-Ethnic Study of Atherosclerosis and AIr Pollution (MESA Air)
American journal of epidemiology, v 176(9), pp 825-837
01 Nov 2012
PMID: 23043127
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) was initiated in 2004 to investigate the relation between individual-level estimates of long-term air pollution exposure and the progression of subclinical atherosclerosis and the incidence of cardiovascular disease (CVD). MESA Air builds on a multicenter, community-based US study of CVD, supplementing that study with additional participants, outcome measurements, and state-of-the-art air pollution exposure assessments of fine particulate matter, oxides of nitrogen, and black carbon. More than 7,000 participants aged 4584 years are being followed for over 10 years for the identification and characterization of CVD events, including acute myocardial infarction and other coronary artery disease, stroke, peripheral artery disease, and congestive heart failure; cardiac procedures; and mortality. Subcohorts undergo baseline and follow-up measurements of coronary artery calcium using computed tomography and carotid artery intima-medial wall thickness using ultrasonography. This cohort provides vast exposure heterogeneity in ranges currently experienced and permitted in most developed nations, and the air monitoring and modeling methods employed will provide individual estimates of exposure that incorporate residence-specific infiltration characteristics and participant-specific time-activity patterns. The overarching study aim is to understand and reduce uncertainty in health effect estimation regarding long-term exposure to air pollution and CVD.
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Details
- Title
- Prospective Study of Particulate Air Pollution Exposures, Subclinical Atherosclerosis, and Clinical Cardiovascular Disease The Multi-Ethnic Study of Atherosclerosis and AIr Pollution (MESA Air)
- Creators
- Joel D. Kaufman - University of WashingtonSara D. Adar - University of WashingtonRyan W. Allen - University of WashingtonR. Graham Barr - University of WashingtonMatthew J. Budoff - University of WashingtonGregory L. Burke - University of WashingtonAdrian M. Casillas - University of WashingtonMartin A. Cohen - University of WashingtonCynthia L. Curl - University of WashingtonMartha L. Daviglus - University of WashingtonAna V. Diez Roux - University of WashingtonDavid R. Jacobs - University of WashingtonRichard A. Kronmal - University of WashingtonTimothy V. Larson - University of WashingtonSally Lee-Jane Liu - University of WashingtonThomas Lumley - University of WashingtonAna Navas-Acien - University of WashingtonDaniel H. O'Leary - Tufts UniversityJerome I. Rotter - University of WashingtonPaul D. Sampson - University of WashingtonLianne Sheppard - University of WashingtonDavid S. Siscovick - University of WashingtonJames H. Stein - University of WashingtonAdam A. Szpiro - University of WashingtonRussell P. Tracy - University of Washington
- Publication Details
- American journal of epidemiology, v 176(9), pp 825-837
- Publisher
- Oxford Univ Press
- Number of pages
- 13
- Grant note
- National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P30DK063491 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K24ES013195 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01HC095159; N01HC095169 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) UL1RR024156 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) RD831697 / Environmental Protection Agency; United States Environmental Protection Agency UL1TR000124 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01HL071251; R01HL071259; R01HL071250; R01HL071051; R01HL071258; R44HL095169; R01HL071252; R43HL095169; R01HL071205 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000310371200011
- Scopus ID
- 2-s2.0-84861999865
- Other Identifier
- 991020111975104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health