Journal article
Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
British journal of dermatology (1951), v 180(2), pp 289-296
Feb 2019
PMID: 29947134
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bakuchiol is a phytochemical that has demonstrated cutaneous antiageing effects when applied topically. Early studies have suggested that bakuchiol is a functional analogue of topical retinoids, as both compounds have been shown to induce similar gene expression in the skin and lead to improvement of cutaneous photodamage. No in vivo studies have compared the two compounds for efficacy and side-effects.
To compare the clinical efficacy and side-effect profiles of bakuchiol and retinol in improving common signs of cutaneous facial ageing.
This was a randomized, double-blind, 12-week study in which 44 patients were asked to apply either bakuchiol 0·5% cream twice daily or retinol 0·5% cream daily. A facial photograph and analytical system was used to obtain and analyse high-resolution photographs of patients at 0, 4, 8 and 12 weeks. Patients also completed tolerability assessment questions to review side-effects. During study visits, a board-certified dermatologist, blinded to study group assignments, graded pigmentation and redness.
Bakuchiol and retinol both significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds. The retinol users reported more facial skin scaling and stinging.
Our study demonstrates that bakuchiol is comparable with retinol in its ability to improve photoageing and is better tolerated than retinol. Bakuchiol is promising as a more tolerable alternative to retinol.
Metrics
Details
- Title
- Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
- Creators
- S Dhaliwal - University of California, DavisI Rybak - University of California, DavisS R Ellis - University of California, DavisM Notay - University of California, DavisM Trivedi - University of Michigan–Ann ArborW Burney - University of California, DavisA R Vaughn - Drexel UniversityM Nguyen - University of California, DavisP Reiter - Nova Southeastern UniversityS Bosanac - School of Medicine, University of California - Davis, Sacramento, CA, U.S.AH Yan - University of California, DavisN Foolad - University of California, DavisR K Sivamani - California State University, Sacramento
- Publication Details
- British journal of dermatology (1951), v 180(2), pp 289-296
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000457747200010
- Scopus ID
- 2-s2.0-85053698608
- Other Identifier
- 991019168118004721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology