Journal article
Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ
The Journal of biological chemistry, v 273(4), pp 1855-1858
23 Jan 1998
PMID: 9442016
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Fat cell differentiation is a critical aspect of obesity and diabetes. Dietary fatty acids are converted to arachidonic acid, which serves as precursor of prostaglandins (PGs). PGJ2 derivatives function as activating ligands for peroxisome proliferator-activated receptor γ (PPARγ), a nuclear hormone receptor that is central to adipogenic determination. We report here that PGF2α blocks adipogenesis through activation of mitogen-activated protein kinase, resulting in inhibitory phosphorylation of PPARγ. Both mitogen-activated protein kinase activation and PPARγ phosphorylation are required for the anti-adipogenic effects of PGF2α. Thus, PG signals generated at a cell surface receptor regulate the program of gene expression required for adipogenesis by modulating the activity of a nuclear hormone receptor that is directly activated by other PG signals. The balance between PGF2α and PGJ2 signaling may thus be central to the development of obesity and diabetes.
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Details
- Title
- Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ
- Creators
- Mauricio J. Reginato - University of PennsylvaniaSamuel L. Krakow - University of PennsylvaniaShannon T. BaileyMitchell A. Lazar - University of Pennsylvania
- Publication Details
- The Journal of biological chemistry, v 273(4), pp 1855-1858
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000071595200005
- Scopus ID
- 2-s2.0-0031939716
- Other Identifier
- 991020100081804721
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- Web of Science research areas
- Biochemistry & Molecular Biology