Journal article
Prostate-Specific Antigen Expression and Lipochrome Pigment Granules in the Differential Diagnosis of Prostatic Adenocarcinoma Versus Seminal Vesicle–Ejaculatory Duct Epithelium
Archives of pathology & laboratory medicine (1976), v 123(11), pp 1093-1097
01 Nov 1999
PMID: 10539914
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
Background.—Lipochrome pigment granules (LPGs) and prostate-specific antigen (PSA) localization have been cited as helpful adjuncts in differentiating atypical histologic patterns of seminal vesicle–ejaculatory duct (SVED) from prostatic adenocarcinoma. However, LPGs have been described in both benign and neoplastic prostatic acini, and PSA expression within the intraprostatic SVED has not been fully explored.
Design.—Fifty radical prostatectomy specimens were studied for LPGs and 9 cases for PSA expression.
Results.—Two morphologic types of LPGs (type 1 and type 2) were observed. The reproducibility in classifying LPGs was evaluated by κ statistics, which demonstrated a strong agreement between 4 observers. Type 1 was restricted to SVED in all 50 specimens. Type 2 was subclassified into 2A and 2B. Type 2 LPGs were observed in prostatic acini of different zones, high-grade prostatic intraepithelial neoplasia, prostatic adenocarcinoma, and occasionally with type 1 LPG in SVED. Focal reactivity for PSA in the distal portion of SVED near urethra was noted in 1 of 9 cases.
Conclusion.—Awareness about morphologic differences between the 2 types of LPGs could help to avoid a potential diagnostic pitfall of misinterpreting SVED epithelium for adenocarcinoma. Caution is recommended in interpreting PSA expression, since rare focal PSA reactivity was observed in the distal SVED.
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Details
- Title
- Prostate-Specific Antigen Expression and Lipochrome Pigment Granules in the Differential Diagnosis of Prostatic Adenocarcinoma Versus Seminal Vesicle–Ejaculatory Duct Epithelium
- Creators
- Vinod B. Shidham - Medical College of WisconsinPaul F. Lindholm - Medical College of WisconsinAndré Kajdacsy-Balla - Medical College of WisconsinZainab Basir - Medical College of WisconsinVarghese George - Medical College of WisconsinFernando U. Garcia - Drexel University
- Publication Details
- Archives of pathology & laboratory medicine (1976), v 123(11), pp 1093-1097
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000083584000024
- Other Identifier
- 991019168556604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medical Laboratory Technology
- Medicine, Research & Experimental
- Pathology