Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with l-lysine and carboxymethylcellulose, maleic anhydride divinyl ether and colony stimulating factor 1

Steven C. Kunder; Linxian Wu; Page S. Morahan

doi:10.1016/0166-3542(93)90030-M

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Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with l-lysine and carboxymethylcellulose, maleic anhydride divinyl ether and colony stimulating factor 1

Journal article

Peer reviewed

Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with l-lysine and carboxymethylcellulose, maleic anhydride divinyl ether and colony stimulating factor 1

Steven C. Kunder, Linxian Wu and Page S. Morahan

Antiviral research, v 21(3)

1993

DOI: https://doi.org/10.1016/0166-3542(93)90030-M

PMID: 7692814

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Abstract

Aged mice

Biological Response Modifiers pICLC

CSF-1

MCMV

MVE-2

SCID mice

A variety of biological response modifiers (BRMs) have provided antiviral protection to immunocompetent mice, and this prompted us to determine their efficacy against murine cytomegalovirus (MCMV) infection in immunocompromised mice-including the profoundly immunocompromised SCID mice and C57B1/6 and B 6D 2F1 aged mice. SCID mice showed a marked decrease (>20-fold) in resistance to MCMV, while there was a slight decrease (3-fold) in aged mice. In BRM antiviral protection studies, SCID mice were almost completely protected against MCMV infection by the pleiotropic immunomodulators, MVE-2 and pICLC, but much less by the more selective CSF-1. pICLC-induced IFN and NK cell cytotoxicity were maintained in SCID mice, suggesting that pleiotropic immunomodulatory effects may be required for antiviral protection in such a profoundly immunocompromised model. pICLC also effectively protected aged mice against lethal MCMV infection and effectively induced IFN. These results emphasize the potential for BRM treatment in immunocompromised hosts.

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Title: Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with l-lysine and carboxymethylcellulose, maleic anhydride divinyl ether and colony stimulating factor 1
Creators: Steven C. Kunder - Drexel University
Linxian Wu - Drexel University
Page S. Morahan - Drexel University
Publication Details: Antiviral research, v 21(3)
Publisher: Elsevier
Resource Type: Journal article
Language: English
Academic Unit: [Retired Faculty]
Web of Science ID: WOS:A1993LM81900004
Scopus ID: 2-s2.0-0027322975
Other Identifier: 991019184071304721

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Web of Science research areas: Pharmacology & Pharmacy; Virology